SynthesisRenal failure2025
Efficacy of Shenkang Injection combined with renin-angiotensin-aldosterone system blockers in diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- The Mechanism and Application of Traditional Chinese Medicine Nano-Formulations in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026Review
- Effects of Shenkang for chronic kidney disease: a propensity score matched with network pharmacology analysis.Renal failure · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveShenkang injection (SKI), a Traditional Chinese Medicine formulation, is widely used in China for diabetic nephropathy (DN). This systematic review and meta-analysis aimed to evaluate the efficacy and safety of SKI combined with renin-angiotensin-aldosterone system (RAAS) blockers in patients with DN.
methodsA comprehensive search of seven databases was conducted up to September 18, 2024, for randomized controlled trials (RCTs) comparing SKI plus RAAS blockers versus RAAS blockers alone in DN patients. Meta-analysis was performed using RevMan 5.3 and Stata 17.0, with effect sizes expressed as weighted mean differences (WMDs) or odds ratios (ORs) with 95% confidence intervals (CIs).
resultsA total of 18 RCTs involving 1,497 patients were analyzed. Combination therapy significantly improved total effective rate (TER) (MD 2.61, 95% CI 1.62-2.64) and reduced key renal and metabolic markers. Urinary protein excretion rate (UPER), serum creatinine (SCr), blood urea nitrogen (BUN), 24-hour urinary protein (24h-UTP), total cholesterol (TC), and triglyceride (TG) levels all significantly decreased in the combination group. Subgroup analysis showed that patients aged ≤55 years had greater reductions in SCr (WMD -25.62, 95% CI -29.41 to -21.83) and BUN (WMD -2.51, 95% CI -2.75 to -2.27). Sensitivity analysis confirmed the robustness of findings. No publication bias was detected for TER, SCr, BUN, 24h-UTP, TG, and adverse reactions, though UPER and TC showed potential bias.
conclusionSKI combined with RAAS blockers may enhance renal function and metabolic profiles in DN patients. Further high-quality RCTs are needed to validate these findings and assess long-term safety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.