Evidence map›Paper›PMID 40425565›Full record

ArticleNPJ science of food2025

Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans: a meta-omics study.

Esther Mezhibovsky, Guojun Wu, Yue Wu, Zhibin Ning, Karen Bacalia, Sriya Sadangi, Riddhi Patel, Alexander Poulev, Rocio M Duran, Marie Macor and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04018066 (The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04018066 nacompletednot on this map

The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2019 to 2019Enrolled34ConditionsMechanisms, DefenseArmsGP-SPI
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Esther MezhibovskyDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Guojun WuDepartment of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Yue WuDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Zhibin NingOttawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Karen BacaliaDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Sriya SadangiDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Riddhi PatelDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Alexander PoulevDepartment of Plant Biology, School of Environmental and Biological Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Rocio M DuranDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Marie MacorDepartment of Surgery, Rutgers Robert Wood Johnson Medical School (RWJMS), New Brunswick, 08903, NJ, USA.
Susette CoyleDepartment of Surgery, Rutgers Robert Wood Johnson Medical School (RWJMS), New Brunswick, 08903, NJ, USA.
Yan Y LamDepartment of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Ilya RaskinDepartment of Plant Biology, School of Environmental and Biological Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Daniel FigeysOttawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Liping ZhaoDepartment of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Diana E RoopchandDepartment of Food Science and New Jersey Institute for Food, Nutrition and Health (Rutgers Center for Lipid Research), School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. roopchand@sebs.rutgers.edu.

Funding

Proanthocyanidin metabolites produced by commensal gut microbes may promote metabolic resilienceR01AT010242 · NCCIH · RUTGERS, THE STATE UNIV OF N.J. · PI ROOPCHAND, DIANA ELIZABETH · 2018 to 2021
$1.5M
NCCIH NIH HHS R01 AT010242NIH HHS R01 AT010242
6 · The paper itself

Abstract

Grape polyphenols (GPs) are rich in B-type proanthocyanidins, which promote metabolic resilience. Longitudinal metabolomic, metagenomic, and metaproteomic changes were measured in 27 healthy subjects supplemented with soy protein isolate (SPI, 40 g per day) for 5 days followed by GPs complexed to SPI (GP-SPI standardized to 5% GPs, 40 g per day) for 10 days. Fecal, urine, and/or fasting blood samples were collected before supplementation (day -5), after 5 days of SPI (day 0), and after 2, 4 and 10 days of GP-SPI. Most multi-omic changes observed after 2 and/or 4 days of GP-SPI intake were temporary, returning to pre-supplementation profiles by day 10. Shotgun metagenomics sequencing provided insights that could not be captured with 16S rRNA amplicon sequencing. Notably, 10 days of GP-SPI decreased fasting blood glucose and increased serum hyocholic acid (HCA), a glucoregulatory bile acid, which negatively correlated with one gut bacterial guild. In conclusion, GP-induced suppression of a bacterial guild may lead to higher HCA and lower fasting blood glucose.

Identifiers

PMID40425565
PMCPMC12116990

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.