ArticleScientific reports2025
Phylogenetic insights into Leishmania species circulating among humans, vectors, and reservoir hosts in Shiraz, Southern Iran: implications for leishmaniasis control.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Zoonotic transmission and genetic diversity ofParasite epidemiology and control · 2026Article
- Arab Medical Tourists in Iran: A Phenomenological Study of Lived Experience.Health science reports · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leishmaniasis remains a significant public health challenge in southern Iran, particularly in the Fars province, where Shiraz is a major focus of the disease. This study aimed to elucidate the phylogenetic relationships of Leishmania species isolated from humans, sand flies, and reservoir hosts in Shiraz and its suburbs. Cutaneous slit biopsies were collected from 350 suspected human cases of cutaneous leishmaniasis (CL), and samples were also obtained from rodents (Tatera indica) and sand flies (Phlebotomus papatasi). Parasites were cultured, and DNA was extracted for PCR amplification of the minicircle kinetoplast DNA (kDNA) gene. Phylogenetic analysis was performed using Neighbor-Joining and Maximum Likelihood methods. The results revealed the presence of Leishmania major, L. tropica, and L. infantum, with L. major being the predominant species. Phylogenetic trees demonstrated high genetic similarity between local isolates and those from other regions, including Iran, the UK, and Spain. This study highlights the complex transmission dynamics of Leishmania in Shiraz and underscores the need for targeted control strategies. The findings contribute to a deeper understanding of the genetic diversity and evolutionary relationships of Leishmania species in endemic regions.
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