Evidence map›Paper›PMID 40425671›Full record

ArticleScientific reports2025

Integrative in silico and in vivo Drosophila model studies reveal the anti-inflammatory, antioxidant, and anticancer properties of red radish microgreen extract.

Trina Ekawati Tallei, Nova Hellen Kapantow, Nurdjannah Jane Niode, Sofia Safitri Hessel, Maghfirah Savitri, Fatimawali Fatimawali, Sojin Kang, Moon Nyeo Park, Muhammad Raihan, Widya Hardiyanti and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Trina Ekawati TalleiDepartment of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia. trina_tallei@unsrat.ac.id.
Nova Hellen KapantowDepartment of Nutrition, Faculty of Medicine, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia.
Nurdjannah Jane NiodeDepartment of Dermatology and Venereology, Faculty of Medicine, Sam Ratulangi University, Prof. Dr. R.D. Kandou Hospital Manado, Manado, 95115, North Sulawesi, Indonesia.
Sofia Safitri HesselDepartment of Biotechnology, Indonesia Biodiversity and Biogeography Research Institute (INABIG), Bandung, 40132, West Java, Indonesia.
Maghfirah SavitriFaculty of Medicine, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia.
Fatimawali FatimawaliPharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia.
Sojin KangDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul, 02447, South Korea.
Moon Nyeo ParkDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul, 02447, South Korea.
Muhammad RaihanDepartment of Pharmaceutical Science and Technology, Faculty of Pharmacy, Universitas Hasanuddin, Tamalanrea, 90245, Makassar, Indonesia.
Widya HardiyantiFaculty of Pharmacy, UNHAS Fly Research Group, Hasanuddin University, Tamalanrea, 90245, Makassar, Indonesia.
Firzan NainuFaculty of Pharmacy, UNHAS Fly Research Group, Hasanuddin University, Tamalanrea, 90245, Makassar, Indonesia.
Bonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul, 02447, South Korea. bongleekim@khu.ac.kr.

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education NRF-2020R1I1A2066868Directorate of Research, Technology, and Community Service and the Directorate General of Higher Education, Research, and Technology of the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia 084/E5/PG.02.00.PL/2024
6 · The paper itself

Abstract

Red radish microgreens (RRM) have gained considerable attention for their promising therapeutic potential. However, the molecular mechanisms underlying their bioactivity remain inadequately characterized. This study explores the anti-inflammatory, antioxidant, and anticancer properties of RRM extract using in silico and in vivo Drosophila model analyses. The metabolite profile of the RRM extract was characterized using comprehensive metabolomics techniques, including Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography High-Resolution Mass Spectrometry (LC-HRMS). Furthermore, in silico analysis utilizing network pharmacology identified target proteins of RRM compounds associated with cancer, inflammation, and oxidative stress. Concurrently, in vivo experiments with Drosophila melanogaster PGRP-LB

Indexed as

Anti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsPlant ExtractsRaphanusAnimalsComputer SimulationDrosophila melanogasterMolecular Docking SimulationOxidative StressAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsPlant ExtractsDrosophilaFunctional foodMolecular mechanismsNetwork PharmacologyRed radish microgreens

Identifiers

PMID40425671
PMCPMC12116942

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.