Evidence map›Paper›PMID 40425675›Full record

ArticleScientific reports2025

Paxilline derived from an endophytic fungus of Baphicacanthus cusia alleviates hepatocellular carcinoma through autophagy-mediated apoptosis.

Yin Yuan, Jing Yu, Meng Li, Tian Zhou, Zhaoyou Deng, Cuiyun Yin, Xuanchao Shi, Deying Tang, Yiran Liu, Yihang Li

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yin YuanYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China.
Jing YuYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China.
Meng LiCollege of Pharmacy, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Tian ZhouHeilongjiang University of Chinese Medicine, Harbin, 150040, China.
Zhaoyou DengYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China.
Cuiyun YinYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China.
Xuanchao ShiYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China.
Deying TangYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China.
Yiran LiuHeilongjiang University of Chinese Medicine, Harbin, 150040, China.
Yihang LiYunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xishuangbanna Dai Autonomous Prefecture, 666100, China. 48466685@qq.com.

Funding

Yunnan Fundamental Research Projects 202401AU070034
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a malignancy for which no effective drugs are available. Paxilline is derived from an endophytic fungus of the leaves of Baphicacanthus cusia (Nees) Bremek. In a previous study, we found that paxilline inhibited the proliferation of HepG2 cells; however, its mechanism remains unclear. In this study, ESI

Indexed as

AcanthaceaeApoptosisAutophagyCarcinoma, HepatocellularLiver NeoplasmsCell MovementCell ProliferationCell SurvivalEndophytesHep G2 CellsHumansMolecular Docking SimulationSignal TransductionApoptosisAutophagyHepatocellular carcinomaNetwork pharmacologyPaxilline

Identifiers

PMID40425675
PMCPMC12117046

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.