Evidence map›Paper›PMID 40425722›Full record

ArticleCommunications biology2025

High efficiency rare earth element bioleaching with systems biology guided engineering of Gluconobacter oxydans.

Alexa M Schmitz, Brooke Pian, Sabrina Marecos, Mingming Wu, Megan Holycross, Esteban Gazel, Matthew C Reid, Buz Barstow

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Direct evidence of acid-driven protein desolvation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexa M SchmitzDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA.
Brooke PianDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA.
Sabrina MarecosDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-5852-9933
Mingming WuDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-7846-3580
Megan HolycrossDepartment of Earth and Atmospheric Sciences, Cornell University, Ithaca, NY, USA.
Esteban GazelDepartment of Earth and Atmospheric Sciences, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-6385-7672
Matthew C ReidSchool of Civil and Environmental Engineering, Cornell University, Ithaca, NY, USA.
Buz BarstowDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA. bmb35@cornell.edu.ORCID http://orcid.org/0000-0003-2218-6152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological methods are a promising route for the environmentally-friendly production of rare earth elements (REE), which are essential for sustainable energy and defense technologies. In earlier work we identified the key genetic mechanisms contributing to the REE-bioleaching capability of Gluconobacter oxydans B58. Here we have targeted two of these mechanisms to generate a high-efficiency bioleaching strain of G. oxydans. Disruption of the phosphate-specific transport system through a clean deletion of pstS constitutively turns on the phosphate starvation response, yielding a much more acidic biolixiviant, and increasing bioleaching by up to 30%. Coupling knockout of pstS with the over-expression of the mgdh membrane-bound glucose dehydrogenase gene using the P

Indexed as

Gluconobacter oxydansMetals, Rare EarthSystems BiologyBacterial ProteinsMetabolic EngineeringBacterial ProteinsMetals, Rare Earth

Identifiers

PMID40425722
PMCPMC12117071

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.