Evidence map›Paper›PMID 40425988›Full record

ArticleJournal of thrombosis and thrombolysis2025

Outcomes of patients with in-hospital stroke with and without active cancer.

Hiroyuki Kawano, Ayumi Sakurai, Yuuki Takizawa, Risa Toyota, Reona Miwa, Hayate Onuki, Ayane Kawatake, Atsushi Yamamichi, Mikito Saito, Kaoru Nakanishi and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Thrombosis in patients with cancer: challenges and advances.Journal of thrombosis and thrombolysis · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hiroyuki KawanoDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan. hkawano@ks.kyorin-u.ac.jp.
Ayumi SakuraiStroke Center, Kyorin University Hospital, 6-20-2, Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Yuuki TakizawaStroke Center, Kyorin University Hospital, 6-20-2, Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Risa ToyotaDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Reona MiwaDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Hayate OnukiDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Ayane KawatakeDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Atsushi YamamichiDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Mikito SaitoDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Kaoru NakanishiDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Eisaku TsujiDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Shinya TomariDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Yuko HondaDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Yoshiko UnnoDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.
Mayumi UchidaStroke Center, Kyorin University Hospital, 6-20-2, Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Teruyuki HiranoDepartment of Stroke and Cerebrovascular Medicine, Kyorin University, 6-20-2, Shinkawa, Tokyo, 181-8611, Mitaka, Japan.

Funding

Japan Society for the Promotion of Science 24K10627
6 · The paper itself

Abstract

backgroundCancer is common in patients with ischemic stroke. The aim was to reveal the differences in acute management and outcomes of patients with in-hospital acute ischemic stroke (IHS) with and without active cancer.

methodsTwo hundred IHS patients (58% male, median age 78 years, median NIHSS score 9) from August 2016 to July 2023 at our institution were divided into two groups: 70 with active cancer (IHS-AC 35%) and 130 without AC (IHS-nonAC 65%). Patients' characteristics, time intervals, and clinical outcomes were compared between the groups. A good clinical outcome was defined as modified Rankin Scale score 0-3.

resultsIHS was identified most frequently by a nurse (IHS-AC group 67%, IHS-nonAC group 71%). Time from recognition to stroke physician assessment (37 vs. 90 min, p = 0.008) was shorter in the IHS-AC group. Good clinical outcomes at discharge (31% in each group, p = 1.000) and in-hospital mortality (IHS-AC group 29%, IHS-nonAC group 21%, p = 0.225) were similar in the groups. The rates of reperfusion therapy (intravenous rt-PA and/or mechanical thrombectomy) were 16% in the IHS-AC group and 15% in the IHS-nonAC group (p = 1.000). The rates of good clinical outcomes and mortality at discharge in patients with reperfusion therapy were each 36%. DISCUSSION AND

conclusionOne-third of IHS patients had comorbid active cancer. The rates of reperfusion therapy and good clinical outcomes were similar in groups with and without active cancer. Acute stroke management should not be withheld solely based on cancer.

Indexed as

Ischemic StrokeNeoplasmsStrokeAgedAged, 80 and overFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesThrombectomyThrombolytic TherapyTreatment OutcomeCancerIn-hospitalStrokeStroke codeThrombectomyThrombolysis

Identifiers

PMID40425988

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.