Evidence map›Paper›PMID 40426120›Full record

ReviewJournal of nanobiotechnology2025

"Double-sided protector" Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects.

Laijun Xu, Junyi Zhang, Junsi Luo, Yiteng Cui, Jinhong Chen, Bin Zeng, Zhiyuan Deng, Longquan Shao

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
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  8. Genipin-crosslinked CeORSC advances · 2026
    Article
  9. Review
  10. Review
  11. Article
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  13. Article
  14. Review
  15. Article
  16. Dextran-based stimuli-responsive hydrogels for smart dressings in wound healing.Journal of materials science. Materials in medicine · 2026
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laijun Xu *Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Junyi Zhang *Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Junsi LuoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Yiteng CuiHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Jinhong ChenStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Bin ZengSchool of Stomatology, Changsha Medical University, Changsha, 410219, China.
Zhiyuan DengHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China. drdengzhiyuan@csu.edu.cn.
Longquan ShaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China. shaolongquan@smu.edu.cn.

Funding

Hunan Provincial Health Commission Scientific Research Project 202208015033Southern Medical University Stomatology Hospital'Scientific Research Cultivation Program'-Postdoctoral Special Project PY2023012The National Natural Science Foundation of China 82201081The National Natural Science Foundation of China 82271025
6 · The paper itself

Abstract

Skin and mucous membranes serve as crucial barrier tissues within the human body. Defective wound healing not only inflicts pain but also heightens the risk of infection and impairs immune function. Janus hydrogels possess two-sided distinct asymmetric structures that endow them with diverse properties such as high water absorbency, flexibility, anti-adhesion ability etc. These hydrogels also exhibit great potential in biofluid transport, drug delivery and promoting tissue repair. Currently, research efforts predominantly concentrate on the preparation techniques, properties, and biomedical applications. This review summarized its structural characteristics and different forms of designations, and focused on the possible mechanisms, the existing problems and improvement strategies for the skin and mucous tissues wound, aiming to provide new design ideas for repairing complex skin and mucous membrane tissue defects.

Indexed as

HydrogelsMucous MembraneSkinWound HealingAnimalsBiocompatible MaterialsDrug Delivery SystemsHumansBiocompatible MaterialsHydrogelsBiomedical applicationsJanus hydrogelsRegenerative medicineSkin and mucosal repairTissue engineering

Identifiers

PMID40426120
PMCPMC12117736

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.