Evidence map›Paper›PMID 40426270›Full record

ReviewBioData mining2025

Network-based analyses of multiomics data in biomedicine.

Rachit Kumar, Joseph D Romano, Marylyn D Ritchie

Abstract readReview
In one paragraph

Review in BioData mining, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachit KumarGenomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Joseph D RomanoDivision of Informatics, Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marylyn D RitchieDivision of Informatics, Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. marylyn@pennmedicine.upenn.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Technology Identification and Training CoreP30AG073105 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DEMIRIS, GEORGE, KARLAWISH, JASON H · 2021 to 2025
$21.2M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
Discovering clinical endpoints of toxicity via graph machine learning and semantic data analysisR00LM013646 · NLM · UNIVERSITY OF PENNSYLVANIA · PI ROMANO, JOSEPH DANIEL · 2023 to 2025
$646k
NIA NIH HHS P30AG073105NIA NIH HHS U01 AG066833NIEHS NIH HHS P30 ES013508NIGMS NIH HHS T32 GM007170NIH HHS R00LM013646NIH HHS T32GM007170NIH HHS U01AG066833NLM NIH HHS R00 LM013646
6 · The paper itself

Abstract

Network representations of data are designed to encode relationships between concepts as sets of edges between nodes. Human biology is inherently complex and is represented by data that often exists in a hierarchical nature. One canonical example is the relationship that exists within and between various -omics datasets, including genomics, transcriptomics, and proteomics, among others. Encoding such data in a network-based or graph-based representation allows the explicit incorporation of such relationships into various biomedical big data tasks, including (but not limited to) disease subtyping, interaction prediction, biomarker identification, and patient classification. This review will present various existing approaches in using network representations and analysis of data in multiomics in the framework of deep learning and machine learning approaches, subdivided into supervised and unsupervised approaches, to identify benefits and drawbacks of various approaches as well as the possible next steps for the field.

Indexed as

Deep learningGraphsMachine learningMultiomicsNetworksReviewSupervised learningUnsupervised learning

Identifiers

PMID40426270
PMCPMC12117783

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.