Evidence map›Paper›PMID 40426608›Full record

ArticleBrain sciences2025

Exploring the Impact of Backward and Forward Locomotor Treadmill Training in Chronic Stroke Survivors with Severe Post-Stroke Walking Impairment: A Single-Center Pilot Randomized Controlled Trial.

Saiprasad Naidu, Khwahish Singh, Tamiel Murray, Colin Drury, Erin Palermo, Heidi J Sucharew, Changchun Xie, Pierce Boyne, Kari Dunning, Oluwole O Awosika

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Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Saiprasad NaiduDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Khwahish SinghDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0009-0000-6997-6392
Tamiel MurrayDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Colin DruryDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-0999-3905
Erin PalermoDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Heidi J SucharewDepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Changchun XieDepartment of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati, Cincinnati, OH 45267, USA.
Pierce BoyneDepartment of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH 45267, USA.
Kari DunningDepartment of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH 45267, USA.
Oluwole O AwosikaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-5286-931X

Funding

CinciNext Pilot Grant N/A
6 · The paper itself

Abstract

backgroundDefined as a self-selected speed of <0.4 m/s, chronic stroke survivors falling in this category are classified as "severe", usually homebound and sedentary, and they experience worse outcomes. Limited rehabilitation strategies are available to improve walking speed and related outcomes in this subgroup, and questions regarding effective rehabilitation options remain. The objective of this study was to determine the effects of backward (BLTT) and forward (FLTT) locomotor treadmill training on overground walking speed, spatiotemporal symmetry, and dynamic postural stability.

methodsIn this single-center, assessor-blinded, randomized controlled pilot trial, 14 stroke survivors with severe waking impairment underwent 12 sessions of BLTT (

resultsTwo subjects in the BLTT group (28.6%) and one (14.3%) in FLTT achieved MCID following training; however, most subjects did not, with significant variability in response. At 24 h POST, the median (IQR) percent change in walking speed was 28.9 (9.01-36.7) and 17.4 (12.6-39.7) with BLTT and FLTT, respectively; however, no between-group differences were seen (

conclusionsWhile preliminary, this study found that 12 training sessions did not lead to group-level achievement of MCID for walking speed in our cohort and found no significant between-group differences in walking capacity or dynamic postural stability. Future well-powered dosing trials and mechanistically driven studies are needed to optimize and identify predictors of training response.

Indexed as

backward walkingdynamic postural stabilitygaitoutcome measuressensorineural integrationsevere strokesevere walking impairmentstroke recoverystroke rehabilitationwalking capacity

Identifiers

PMID40426608
PMCPMC12110432

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.