Evidence map›Paper›PMID 40427469›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Manganese Porphyrin Treatment Improves Redox Status Caused by Acute Compressive Spinal Cord Trauma.

Raquel Vieira Niella, Janaína Maria Xavier Corrêa, Claire Souza da Costa Marques, Álvaro José Chávez Silva, Luciano Cardoso Santos, Iago Santos de Oliveira, Gilson DeFreitas-Silva, Júlio Santos Rebouças, Juneo Freitas Silva, Mário Sérgio Lima de Lavor

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raquel Vieira NiellaDepartment of Agricultural and Environmental Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.
Janaína Maria Xavier CorrêaDepartment of Agricultural and Environmental Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.
Claire Souza da Costa MarquesDepartment of Agricultural and Environmental Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.
Álvaro José Chávez SilvaDepartment of Agricultural and Environmental Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.
Luciano Cardoso SantosDepartment of Biological Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.ORCID 0000-0001-7679-1353
Iago Santos de OliveiraDepartment of Agricultural and Environmental Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.
Gilson DeFreitas-SilvaDepartment of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte 30270901, MG, Brazil.ORCID 0000-0002-9272-8466
Júlio Santos RebouçasDepartment of Chemistry, Institute of Exact and Natural Sciences, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil.ORCID 0000-0003-3818-029X
Juneo Freitas SilvaDepartment of Biological Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.ORCID 0000-0002-9881-1236
Mário Sérgio Lima de LavorDepartment of Agricultural and Environmental Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.ORCID 0000-0003-0795-5320

Funding

CNPQ 140816/2020-8Proap - CAPES 88881.693767/2022-01
6 · The paper itself

Abstract

There is increasing interest in identifying drugs that can prevent or delay neurological complications following spinal cord injury, thus expanding the therapeutic window for other potential neuroprotective agents. In this context, manganese porphyrins (MnPs) have shown high antioxidant and anti-inflammatory potential in various experimental disease models, including stroke, cancer, diabetes, ischemia, and radiotherapy. However, they have been little evaluated in spinal cord injuries. This study aimed to assess the therapeutic potential of the manganese porphyrins [MnTE-2-PyP]

Indexed as

apoptosisendoplasmic reticulum stressneuroprotectionoxidative stress

Identifiers

PMID40427469
PMCPMC12108513

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.