Evidence map›Paper›PMID 40427470›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Hydrogen Peroxide-Induced Re-Expression of Repressor Element 1-Silencing Transcription Factor Contributes to Cardiac Vagal Dysfunction in Type 2 Diabetes Mellitus.

Dongze Zhang, Huiyin Tu, Wenfeng Hu, Yu Li, Michael C Wadman, Yu-Long Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongze ZhangDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Huiyin TuDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-1662-2088
Wenfeng HuDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yu LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michael C WadmanDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-5688-6707
Yu-Long LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-5407-2761

Funding

Mechanisms of cardiac sympathetic hyperactivity in chronic heart failureR01HL137832 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 to 2025
$1.3M
Potential mechanism underlying parasympathetic neuronal dysfunction in diabetesR01HL168500 · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2025 to 2025
$603k
NHLBI NIH HHS R01 HL137832NHLBI NIH HHS R01 HL144146NHLBI NIH HHS R01 HL168500NIH HHS R01HL144146NIH HHS R01HL168500
6 · The paper itself

Abstract

Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), is a major health problem worldwide and has become a leading cause of mortality. As a common complication of patients with T2DM, cardiac autonomic dysfunction (including sympathetic overactivation and reduced vagal tone) is associated with a higher risk of arrhythmia-related sudden cardiac death. Our previous study found that T2DM-elevated hydrogen peroxide (H

Indexed as

antioxidantcardiac vagal neuronshydrogen peroxideN-type Ca2+ channelsRESTtype 2 diabetes mellitus

Identifiers

PMID40427470
PMCPMC12108343

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.