Evidence map›Paper›PMID 40427599›Full record

ArticleBiomolecules2025

Discovery and Characterisation of Novel Poly-Histidine-Poly-Glycine Peptides as Matrix Metalloproteinase Inhibitors.

He Wang, Wenchao Cai, Zhiyu Tang, Juanli Fu, Enrico König, Nanwen Zhang, Xiaole Chen, Tianbao Chen, Chris Shaw

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

He WangSchool of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350000, China.
Wenchao CaiDepartment of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou 350000, China.
Zhiyu TangDepartment of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou 350000, China.
Juanli FuSchool of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350000, China.
Enrico KönigLaboratory of Synthetic and Structural Vaccinology, University of Trento, 38100 Trento, Italy.ORCID 0000-0002-1560-5948
Nanwen ZhangDepartment of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou 350000, China.ORCID 0000-0002-6711-1560
Xiaole ChenDepartment of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou 350000, China.ORCID 0000-0001-9986-5044
Tianbao ChenMedicine Natural Peptide Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT7 1NN, UK.ORCID 0000-0001-8011-9260
Chris ShawMedicine Natural Peptide Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT7 1NN, UK.

Funding

Natural Science Foundation of Fujian Province, China 2021J01892
6 · The paper itself

Abstract

For the first time, two poly-histidine-poly-glycine peptides (pHpG-H5 and pHpG-H7) were identified as promising candidates for matrix metalloproteinase inhibitors. cDNAs encoding pHpG-H5 and pHpG-H7 peptides were isolated from the

Indexed as

HistidineMatrix Metalloproteinase 1Matrix Metalloproteinase InhibitorsPeptidesAmino Acid SequenceCell MovementHumansHistidineMatrix Metalloproteinase 1Matrix Metalloproteinase InhibitorsPeptidespolyglycinepolyhistidinematrix metalloproteinasesmolecular cloningpeptide inhibitorsnake venom

Identifiers

PMID40427599
PMCPMC12108757

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.