Evidence map›Paper›PMID 40427607›Full record

ArticleBiomolecules2025

Hydroxytyrosyl Eicosapentaenoate as a Potential Antioxidant for Omega-3 Fatty Acids: Improved Synthesis and Comparative Evaluation with Other Natural Antioxidants.

Natalia García-Acosta, Rosa Cert, Marta Jordán, Luis Goya, Raquel Mateos, Jose Luis Espartero

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia García-AcostaDepartment of Metabolism and Nutrition (DMN), Institute of Food Science, Food Technology, and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 6, 28040 Madrid, Spain.ORCID 0009-0004-1862-2358
Rosa CertFat Institute, Spanish National Research Council (CSIC), Universidad Pablo d Olavide, Edificio 46 Ctra. De Utrera Km 1, 41013 Seville, Spain.ORCID 0000-0003-3972-6522
Marta JordánDepartment of Metabolism and Nutrition (DMN), Institute of Food Science, Food Technology, and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 6, 28040 Madrid, Spain.
Luis GoyaDepartment of Metabolism and Nutrition (DMN), Institute of Food Science, Food Technology, and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 6, 28040 Madrid, Spain.
Raquel MateosDepartment of Metabolism and Nutrition (DMN), Institute of Food Science, Food Technology, and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 6, 28040 Madrid, Spain.ORCID 0000-0002-9722-1939
Jose Luis EsparteroDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain.ORCID 0000-0001-9926-7757

Funding

Ministerio de Ciencia, Innovación y Universidades (MICIN), 316 and Agencia Estatal de Investigación (AEI) PID2021-125259OB-I00
6 · The paper itself

Abstract

Hydroxytyrosol (HT), the primary phenolic compound in virgin olive oil, has notable cardiovascular benefits, particularly in preventing low-density lipoprotein (LDL) oxidation. However, its hydrophilicity limits its solubility and integration into lipid-based formulations. This study aimed to enhance its lipophilicity by synthesizing hydroxytyrosyl eicosapentaenoate (HT-EPA), a derivative of HT and eicosapentaenoic acid (EPA), using a one-step enzymatic catalysis with lipase B from

Indexed as

AntioxidantsEicosapentaenoic AcidFatty Acids, Omega-3Phenylethyl AlcoholFungal ProteinsLipaseOxidation-Reduction3,4-dihydroxyphenylethanolAntioxidantsEicosapentaenoic AcidFatty Acids, Omega-3Fungal ProteinsLipaselipase B, Candida antarcticaPhenylethyl Alcoholantioxidant capacityenzymatic synthesishydroxytyrosolhydroxytyrosyl eicosapentaenoateomega-3 fatty acids

Identifiers

PMID40427607
PMCPMC12109313

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.