Evidence map›Paper›PMID 40427725›Full record

ArticleBiology2025

Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease Myopathy.

Trevor Wilkinson, Emma Fletcher, Andrew Ring, Cassandra Bradley, Evlampia Papoutsi, Dimitrios Miserlis, Robert S Smith, William T Bohannon, Iraklis I Pipinos, Panagiotis Koutakis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Iron Dysregulation and Vascular Diseases: A Contemporary Review.Journal of the American Heart Association · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Trevor WilkinsonDepartment of Biology, Baylor University, Waco, TX 76798, USA.ORCID 0009-0006-8925-8957
Emma FletcherDepartment of Public Health, University of West Florida, Pensacola, FL 32514, USA.ORCID 0000-0001-9646-1722
Andrew RingDepartment of Biology, Baylor University, Waco, TX 76798, USA.ORCID 0000-0002-0426-4690
Cassandra BradleyDepartment of Biology, Baylor University, Waco, TX 76798, USA.ORCID 0000-0002-5149-566X
Evlampia PapoutsiDepartment of Public Health, University of West Florida, Pensacola, FL 32514, USA.ORCID 0009-0001-7186-2498
Dimitrios MiserlisDepartment of Surgery and Perioperative Care, Dell Medical School, University of Texas, Austin, TX 78712, USA.ORCID 0000-0002-2407-4552
Robert S SmithDepartment of Surgery, Baylor Scott and White Medical Center, Temple, TX 76508, USA.
William T BohannonDepartment of Surgery, Baylor Scott and White Medical Center, Temple, TX 76508, USA.
Iraklis I PipinosDepartment of Surgery, University of Nebraska at Medical Center, Omaha, NE 68198, USA.
Panagiotis KoutakisDepartment of Biology, Baylor University, Waco, TX 76798, USA.ORCID 0000-0002-8352-5667

Funding

The Role of microRNA-210 in regulating oxidative stress in patients with peripheral artery diseaseR01AG064420 · NIA · UNIVERSITY OF WEST FLORIDA · PI KOUTAKIS, PANAGIOTIS · 2019 to 2023
$3.3M
NIA NIH HHS R01AG064420
6 · The paper itself

Abstract

This study investigates ferroptosis in the context of peripheral artery disease (PAD), a vascular disease characterized by atherosclerosis of the lower extremities. Muscle atrophy and increased oxidative stress are hallmarks of PAD and correlate with worse clinical outcomes. Given ferroptosis' association with oxidative stress, we explored its role in PAD myopathy by examining gene and protein markers related to metabolic pathways implicated in ferroptosis using both human PAD patients and cultured myotubes. Intermittent claudication (IC) PAD patients, critical limb ischemia (CLI) PAD patients, and non-PAD controls were recruited for this study. Calf muscle biopsies were analyzed for gene expression using qPCR, and protein levels were determined by Western blotting. Cultured myotubes treated with the ferroptosis inducer erastin provided an in vitro comparison. Results demonstrated upregulation of ferroptosis markers such as lipid peroxidation and

Indexed as

autophagyferroptosisiron metabolismlipid peroxidationoxidative stressperipheral artery disease

Identifiers

PMID40427725
PMCPMC12108827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.