Evidence map›Paper›PMID 40428059›Full record

ReviewBioengineering (Basel, Switzerland)2025

Large Language Models in Genomics-A Perspective on Personalized Medicine.

Shahid Ali, Yazdan Ahmad Qadri, Khurshid Ahmad, Zhizhe Lin, Man-Fai Leung, Sung Won Kim, Athanasios V Vasilakos, Teng Zhou

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shahid AliSchool of Cyberspace Security, Hainan University, Haikou 570228, China.ORCID 0000-0002-4724-5086
Yazdan Ahmad QadriSchool of Computer Science and Engineering, Yeungnam University, 280, Daehak-ro, Gyeongsan-si 38541, Gyeongsangbuk-do, Republic of Korea.ORCID 0000-0001-5708-1532
Khurshid AhmadDepartment of Health Informatics, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0002-1095-8445
Zhizhe LinSchool of Cyberspace Security, Hainan University, Haikou 570228, China.ORCID 0000-0002-0088-7241
Man-Fai LeungSchool of Computing and Information Science, Anglia Ruskin University, Cambridge CB1 1PT, UK.ORCID 0000-0002-7753-0136
Sung Won KimSchool of Computer Science and Engineering, Yeungnam University, 280, Daehak-ro, Gyeongsan-si 38541, Gyeongsangbuk-do, Republic of Korea.ORCID 0000-0001-8454-6980
Athanasios V VasilakosDepartment of Information and Communication Technology, University of Agder, 4879 Grimstad, Norway.ORCID 0000-0003-1902-9877
Teng ZhouSchool of Cyberspace Security, Hainan University, Haikou 570228, China.ORCID 0000-0003-1920-8891

Funding

Guangdong Basic and Applied Basic Research Foundation 2025A1515010197Hainan Province Higher Education Teaching Reform Project HNJG2024ZD-16National Key Research and Development Program of China 2021YFB2700600National Natural Science Foundation of China 62462021Philosophy and Social Sciences Planning Project of Zhejiang Province 25JCXK006YB
6 · The paper itself

Abstract

Integrating artificial intelligence (AI), particularly large language models (LLMs), into the healthcare industry is revolutionizing the field of medicine. LLMs possess the capability to analyze the scientific literature and genomic data by comprehending and producing human-like text. This enhances the accuracy, precision, and efficiency of extensive genomic analyses through contextualization. LLMs have made significant advancements in their ability to understand complex genetic terminology and accurately predict medical outcomes. These capabilities allow for a more thorough understanding of genetic influences on health issues and the creation of more effective therapies. This review emphasizes LLMs' significant impact on healthcare, evaluates their triumphs and limitations in genomic data processing, and makes recommendations for addressing these limitations in order to enhance the healthcare system. It explores the latest advancements in LLMs for genomic analysis, focusing on enhancing disease diagnosis and treatment accuracy by taking into account an individual's genetic composition. It also anticipates a future in which AI-driven genomic analysis is commonplace in clinical practice, suggesting potential research areas. To effectively leverage LLMs' potential in personalized medicine, it is vital to actively support innovation across multiple sectors, ensuring that AI developments directly contribute to healthcare solutions tailored to individual patients.

Indexed as

artificial intelligence (AI)genomic datalarge language models (LLMs)precision medicine

Identifiers

PMID40428059
PMCPMC12108693

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.