Evidence map›Paper›PMID 40428366›Full record

ArticleGenes2025

Reduced Genetic Diversity of Key Fertility and Vector Competency Related Genes in

Fatoumata Seck, Mouhamadou Fadel Diop, Karim Mané, Amadou Diallo, Idrissa Dieng, Moussa Namountougou, Abdoulaye Diabate, Alfred Amambua-Ngwa, Ibrahima Dia, Benoit Sessinou Assogba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fatoumata SeckMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Mouhamadou Fadel DiopMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Karim ManéMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Amadou DialloInstitut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-8584-9972
Idrissa DiengInstitut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-8584-5592
Moussa NamountougouInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.
Abdoulaye DiabateInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.
Alfred Amambua-NgwaMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.
Ibrahima DiaInstitut Pasteur de Dakar, Dakar 220, Senegal.ORCID 0000-0002-4244-4545
Benoit Sessinou AssogbaMedical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul P.O. Box 273, The Gambia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsecticide resistance challenges the vector control efforts towards malaria elimination and proving the development of complementary tools. Targeting the genes that are involved in mosquito fertility and susceptibility to

methodsFour fertility and parasite susceptibility genes were identified from a systematic review of the literature. The Single Nucleotide Polymorphisms (SNPs) found within the regions spanned by these four genes, genotyped across 2784 wild-caught

resultsAs potential targets for small molecule inhibitors to reduce malaria transmission, our set of four genes associated with

conclusionsThis integrated finding on the genetic features of major malaria vectors' biological factors across natural populations offer new insights for developing sustainable malaria control tools. These loci were reasonably conserved, allowing for the design of effective targeting with small molecule inhibitors towards controlling vector populations and lowering global malaria transmission.

Indexed as

AnophelesInsect ProteinsMosquito VectorsAfrica South of the SaharaAnimalsFemaleFertilityGenetic VariationInsecticide ResistanceMalariaPolymorphism, Single NucleotideInsect ProteinsAnopheles gambiae s.l.fertilitygenesgenetic diversitysub-Saharan Africavector competency

Identifiers

PMID40428366
PMCPMC12111087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.