Evidence map›Paper›PMID 40428397›Full record

SynthesisGenes2025

Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response.

Junyu Chen, Michael P Epstein, Joellen M Schildkraut, Siddhartha P Kar

Abstract readMeta-Analysis
In one paragraph

Synthesis in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Junyu ChenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Michael P EpsteinDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Joellen M SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-0990-9339
Siddhartha P KarEarly Cancer Institute, University of Cambridge, Cambridge CB2 0AH, UK.ORCID 0000-0002-2314-1426

Funding

Ovarian Cancer Survival in African-American WomenR01CA237318 · NCI · EMORY UNIVERSITY · PI LAWSON, ANDREW B., SCHILDKRAUT, JOELLEN M. · 2020 to 2024
$5.9M
Genomic and Transcriptomic Analysis of Breast and Ovarian CancersR01CA211574 · NCI · UNIVERSITY OF VIRGINIA · PI GAYTHER, SIMON ANDREW, SCHILDKRAUT, JOELLEN M. · 2018 to 2022
$3.1M
Quantitative Genetic Models for Exploring Missing Heritability of Alzheimer's DiseaseRF1AG071170 · NIA · EMORY UNIVERSITY · PI CUTLER, DAVID JOSEPH, EPSTEIN, MICHAEL PHILIP · 2020 to 2020
$2.9M
Common biology underlying pleiotropic breast, prostate and ovarian cancer risk lociR01CA259058 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MATTHEW L FREEDMAN, Simon Andrew Gayther · 2022 to 2026
$2.5M
NCI NIH HHS R01 CA211574NCI NIH HHS R01 CA237318NCI NIH HHS R01 CA259058NIA NIH HHS RF1 AG071170NIH HHS R01CA211574NIH HHS R01CA237318NIH HHS R01CA259058NIH HHS RF1AG071170UK Research and Innovation MR/T043202/2
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autoimmune DiseasesNeoplasmsFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansLinkage DisequilibriumMalePolymorphism, Single Nucleotideautoimmune diseaseautoinflammatory diseasebreast cancercancerendometrial cancergenome-wide association studyovarian cancerprostate cancer

Identifiers

PMID40428397
PMCPMC12111551

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.