Evidence map›Paper›PMID 40429707›Full record

ArticleInternational journal of molecular sciences2025

Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications.

Dilvin Semo, Zornitsa Shomanova, Jürgen Sindermann, Michael Mohr, Georg Evers, Lukas J Motloch, Holger Reinecke, Rinesh Godfrey, Rudin Pistulli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. COVID-19: a vascular nightmare unfolding.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dilvin SemoVascular Signalling, Molecular Cardiology, Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.ORCID 0009-0005-4386-8533
Zornitsa ShomanovaInterdisciplinary Heart Failure Section, Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Jürgen SindermannInterdisciplinary Heart Failure Section, Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Michael MohrDepartment of Medicine A, Hematology, Oncology, and Pulmonary Medicine, University Hospital Münster, 48149 Münster, Germany.
Georg EversDepartment of Medicine A, Hematology, Oncology, and Pulmonary Medicine, University Hospital Münster, 48149 Münster, Germany.
Lukas J MotlochDepartment of Internal Medicine II, Paracelsus Medical University, 5020 Salzburg, Austria.
Holger ReineckeVascular Signalling, Molecular Cardiology, Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Rinesh GodfreyVascular Signalling, Molecular Cardiology, Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.
Rudin PistulliDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, 48149 Münster, Germany.ORCID 0000-0001-7676-3942

Funding

Innovative Medizinische Forschung GO121222IZKF SEED SEED/018/23
6 · The paper itself

Abstract

Cardiovascular complications are a hallmark of Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection (PASC), yet the mechanisms driving persistent cardiac dysfunction remain poorly understood. Emerging evidence implicates mitochondrial dysfunction in immune cells as a key contributor. This study investigated whether CD14

Indexed as

Cardiovascular DiseasesDNA DamageDNA, MitochondrialEnergy MetabolismMonocytesPost-Acute COVID-19 SyndromeAdultAgedFemaleHumansLipopolysaccharide ReceptorsMaleMembrane Potential, MitochondrialMiddle AgedOxidative StressReactive Oxygen SpeciesCD14 protein, humanDNA, MitochondrialLipopolysaccharide ReceptorsReactive Oxygen SpeciesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2bioenergetic profileCD14++ monocytesheart failurelong COVID syndromemonocytic mitochondrial dysfunctionmtDNA damageoxidative stress adaptationreactive oxygen species (ROS)seahorse analysis

Identifiers

PMID40429707
PMCPMC12111130

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.