Evidence map›Paper›PMID 40429710›Full record

ArticleInternational journal of molecular sciences2025

Exploring the Phenotypic Heterogeneity and Bioenergetic Profile of the m.13513G>A mtDNA Substitution: A Heteroplasmy Perspective.

Tatiana Krylova, Yulia Itkis, Polina Tsygankova, Denis Chistol, Konstantin Lyamzaev, Vyacheslav Tabakov, Svetlana Mikhaylova, Natalia Nikitina, Galina Rudenskaya, Aysylu Murtazina and 13 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tatiana KrylovaResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-7197-3497
Yulia ItkisResearch Centre for Medical Genetics, 115522 Moscow, Russia.
Polina TsygankovaResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-3998-3609
Denis ChistolResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0001-6519-7375
Konstantin LyamzaevBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.ORCID 0000-0001-9921-8031
Vyacheslav TabakovResearch Centre for Medical Genetics, 115522 Moscow, Russia.
Svetlana MikhaylovaRussian Children's Clinical Hospital, 119571 Moscow, Russia.
Natalia NikitinaState Autonomous Healthcare Institution of the Sverdlovsk Region «Clinical and Diagnostic Center ''Maternal and Child Health Protection''», 620041 Ekaterinburg, Russia.
Galina RudenskayaResearch Centre for Medical Genetics, 115522 Moscow, Russia.
Aysylu MurtazinaResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0001-7023-7378
Tatiana MarkovaResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-2672-6294
Natalia SemenovaResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0001-7041-045X
Natalia BuchinskayaSaint-Petersburg State Medical Diagnostic Center (Genetic Medical Center), 194044 Saint-Petersburg, Russia.ORCID 0000-0002-2335-3023
Elena SaifullinaDepartment of Medical Genetics and Fundamental Medicine, Bashkir State Medical University, 450008 Ufa, Russia.
Hasyanya AksyanovaState Budgetary Healthcare Institution of Nizhny Novgorod Region «Nizhny Novgorod Regional Children's Clinical Hospital», 603005 Nizhny Novgorod, Russia.
Peter SparberResearch Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-9160-0794
Natalia AndreevaResearch Institute of Eye Diseases, 119021 Moscow, Russia.
Natalia VenediktovaResearch Institute of Eye Diseases, 119021 Moscow, Russia.ORCID 0009-0006-1316-0689
Alina IvanushkinaSaint-Petersburg State Budgetary Healthcare Institution City Clinic No. 14, 194021 Saint-Petersburg, Russia.
Daria EliseevaResearch Center of Neurology, 125367 Moscow, Russia.ORCID 0000-0003-2173-927X
Yulia MurakhovskayaI.M. Sechenov First Moscow State Medical University, the Department of Ophthalmology, 119991 Moscow, Russia.
Natalia SheremetResearch Institute of Eye Diseases, 119021 Moscow, Russia.
Ekaterina ZakharovaResearch Centre for Medical Genetics, 115522 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The m.13513G>A (p.Asp393Asn) substitution in the

Indexed as

DNA, MitochondrialElectron Transport Complex IEnergy MetabolismHeteroplasmyLeigh DiseaseMELAS SyndromeOptic Atrophy, Hereditary, LeberAdolescentAdultChildFemaleFibroblastsHumansMaleMembrane Potential, MitochondrialMiddle AgedDNA, MitochondrialElectron Transport Complex IMitochondrial ProteinsMT-ND5 protein, humanheteroplasmyLeighLHONMELASmtDNArespirometry

Identifiers

PMID40429710
PMCPMC12111569

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.