Evidence mapPaperPMID 40429727Full record

ArticleInternational journal of molecular sciences2025

Association of Vitamin D Supplementation with Glutathione Peroxidase (GPx) Activity, Interleukine-6 (IL-6) Levels, and Anxiety and Depression Scores in Patients with Post-COVID-19 Condition.

Iván Ignacio-Mejía, Cindy Bandala, José Francisco González-Zamora, Leslie Chavez-Galan, Ivette Buendia-Roldan, Karina Pérez-Torres, María Zobeida Rodríguez-Díaz, Denilson Xipe Pacheco-Tobón, Saray Quintero-Fabián, Marco Antonio Vargas-Hernández and 8 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Iván Ignacio-MejíaLaboratorio de Medicina Traslacional, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.ORCID 0000-0003-3792-4613
Cindy BandalaEscuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0002-7414-2621
José Francisco González-ZamoraCentro de Investigación Traslacional, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0001-5444-270X
Leslie Chavez-GalanLaboratorio de Inmunología Integrativa, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-2334-0361
Ivette Buendia-RoldanLaboratorio de Investigación Traslacional en Envejecimiento y Enfermedades Fibróticas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-2825-506X
Karina Pérez-TorresLaboratorio de Investigación Traslacional en Envejecimiento y Enfermedades Fibróticas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.
María Zobeida Rodríguez-DíazLaboratorio de Investigación Traslacional en Envejecimiento y Enfermedades Fibróticas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.
Denilson Xipe Pacheco-TobónLaboratorio de Investigación Traslacional en Envejecimiento y Enfermedades Fibróticas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.ORCID 0000-0003-3882-1413
Saray Quintero-FabiánLaboratorio de Medicina Traslacional, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.ORCID 0000-0001-8062-7118
Marco Antonio Vargas-HernándezSubdirección de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.ORCID 0000-0002-2518-2803
Humberto Carrasco-VargasDirección de la Escuela Militar de Medicina, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico.
Ramcés Falfán-ValenciaLaboratorio de HLA, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.ORCID 0000-0001-6877-8124
Gloria Pérez-RubioLaboratorio de HLA, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico.ORCID 0000-0002-6876-1012
Kevin Alexis Hernández-LaraLaboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
Saúl Gómez-ManzoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0003-2095-9182
Daniel Ortega-CuellarLaboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0001-7950-4911
Fredy Ignacio-MejíaHospital Central Militar, Mexico City 11200, Mexico.
Noemí Cárdenas-RodríguezLaboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0002-6580-3440

Funding

Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas C32-22Instituto Nacional de Pediatria 2022/C-015
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) presents with various symptoms, and some patients develop post-COVID-19 condition (PCC). Vitamin D has shown therapeutic potential in COVID-19 and may offer benefits for PCC. The aim of this study was to evaluate the differences associated with two supplementation strategies (bolus and daily) on interleukin-6 (IL-6) levels, glutathione peroxidase (GPx) activity, and clinical outcomes in PCC patients, regardless of whether target 25 (OH) D levels reached the ideal range. We conducted a self-controlled study in which 54 participants with PCC were supplemented with vitamin D

Indexed as

AnxietyCOVID-19DepressionDietary SupplementsGlutathione PeroxidaseInterleukin-6Vitamin DAdultAgedFemaleHumansMaleMiddle AgedSARS-CoV-2Glutathione PeroxidaseIL6 protein, humanInterleukin-6Vitamin Danxietycholecalciferoldepressionglutathione peroxidase activityinterleukin-6long-COVID-19post-COVID-19 conditionrespiratory symptomsvitamin D3 supplementation

Identifiers

PMID40429727
PMCPMC12110956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.