Evidence map›Paper›PMID 40429790›Full record

ReviewInternational journal of molecular sciences2025

The Current Understanding of the Molecular Pathogenesis of Papillary Thyroid Cancer.

Michelle Carnazza, Danielle Quaranto, Nicole DeSouza, Augustine L Moscatello, David Garber, Steven Hemmerdinger, Humayun K Islam, Raj K Tiwari, Xiu-Min Li, Jan Geliebter

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michelle CarnazzaDivision of R&D, General Nutraceutical Technology, LLC, Elmsford, NY 10523, USA.
Danielle QuarantoDepartment of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA.
Nicole DeSouzaDepartment of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA.
Augustine L MoscatelloDepartment of Otolaryngology, New York Medical College, Valhalla, NY 10595, USA.
David GarberDepartment of Otolaryngology, New York Medical College, Valhalla, NY 10595, USA.
Steven HemmerdingerDepartment of Otolaryngology, New York Medical College, Valhalla, NY 10595, USA.
Humayun K IslamDepartment of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA.
Raj K TiwariDepartment of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA.
Xiu-Min LiDepartment of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA.
Jan GeliebterDepartment of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0000-0002-2944-7960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thyroid is a vital endocrine organ that regulates metabolism, heart rate, respiration, digestion, body temperature, brain development, skin and bone maintenance, and reproduction and fertility. Thyroid cancer (TC) is the most common endocrine malignancy, with an estimate of 44,020 new cases in 2025. Incidence has been increasing, most notably at 4-5% per year in young adults. Papillary thyroid cancer (PTC), the most common TC subtype, accounts for approximately 80% of newly diagnosed TC cases. Furthermore, 2290 deaths are expected from the disease in 2025, with survival at over 98% with treatment. However, as PTC occurs most frequently in young women, recurrences are frequent and the 10-year disease-specific survival rate for advanced PTC is less than 50%. This narrative review aims to describe the current understanding of the thyroid gland, the incidence and subtypes of thyroid cancer, and specifically the diagnosis, prognosis, treatment, and recurrence of PTC. This is supplemented by the role of molecular pathways and biomarkers in PTC.

Indexed as

Thyroid Cancer, PapillaryThyroid NeoplasmsBiomarkers, TumorHumansPrognosisBiomarkers, Tumorbiomarkerspapillary thyroid cancerrecurrencethyroid

Identifiers

PMID40429790
PMCPMC12111134

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.