Evidence map›Paper›PMID 40429897›Full record

ArticleInternational journal of molecular sciences2025

Iron Mediates Radiation-Induced Glioblastoma Cell Diffusion.

Stephenson Boakye Owusu, Akalanka B Ekanayake, Alexei V Tivanski, Michael S Petronek

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephenson Boakye OwusuDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-8557-4606
Akalanka B EkanayakeDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-5129-6751
Alexei V TivanskiDepartment of Chemistry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-1528-2421
Michael S PetronekDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-7581-1172

Funding

Holden Comprehensive Cancer Center NIH P30
6 · The paper itself

Abstract

Radiation therapy is a standard of care treatment for patients with glioblastoma. However, patients' survival rate is dismal, with nearly all patients experiencing disease progression after treatment. Enriched iron content associated with increased transferrin receptor (TfR) expression is an indicator of poor glioblastoma patient outcomes; however, the underlying contributions to tumor progression remain elusive. The goal of this present study is to understand how iron metabolism in glioma contributes to radiation-induced glioblastoma cell motility. U251 and a doxycycline-inducible ferritin heavy chain overexpressing U251 (U251 FtH

Indexed as

Brain NeoplasmsGlioblastomaIronAnimalsApoferritinsCell Line, TumorCell MovementFemaleFerritinsHumansMiceMice, NudeReceptors, TransferrinApoferritinsFerritinsIronReceptors, Transferrinferritin overexpressionglioblastomaionizing radiationirontumor migration

Identifiers

PMID40429897
PMCPMC12112530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.