Evidence map›Paper›PMID 40429978›Full record

ArticleInternational journal of molecular sciences2025

Icariin Ameliorates Cyclophosphamide-Induced Renal Encephalopathy by Modulating the NF-κB and Keap1-Nrf2 Signaling Pathways.

Meiling Shi, Hong Kan, Yijia Tang, Lanshi Tian, Xiangjuan Guo, Weijia Chen, Jianan Geng, Ying Zong, Yunfeng Bi, Zhongmei He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Icariin Against Neurodegeneration: A Focus in Cell Death Pathways.International journal of molecular sciences · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meiling ShiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Hong KanCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Yijia TangSchool of Life Sciences, Jilin University, Changchun 130118, China.
Lanshi TianCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Xiangjuan GuoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Weijia ChenCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Jianan GengCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Ying ZongCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0003-0730-0519
Yunfeng BiCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Zhongmei HeCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.

Funding

Development of health food for improving bone density with Korean Epimedium as raw material 20220401108YYJilin Science &Technology Development Plan under Grant 20220304002YYKey technology and industrialization research of a calcium supplement product - deer gluten chelated calcium project No 20240601086RCStudy on key technology and industrialization of deer heart peptide product, a special diet that canincrease exercise endurance 23JQ08
6 · The paper itself

Abstract

Chemotherapy-induced renal encephalopathy (RE) is a disease characterized by cognitive impairment of the brain caused by impaired kidney function for which there is no definitive treatment. Icariin (ICA), the main active component of

Indexed as

Brain DiseasesCyclophosphamideFlavonoidsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2NF-kappa BSignal TransductionAnimalsApoptosisDisease Models, AnimalHEK293 CellsHumansMaleMiceMice, Inbred C57BLCyclophosphamideFlavonoidsicariinKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2NF-kappa Bapoptosiscognitive impairmentcyclophosphamideicariininflammationserotonin

Identifiers

PMID40429978
PMCPMC12111934

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.