Evidence map›Paper›PMID 40430049›Full record

ArticleInternational journal of molecular sciences2025

Acetazolamide-Loaded Nanoparticle Based on Modified Hyaluronic Acid as Delivery System to Target Carbonic Anhydrases in

Valentina Verdoliva, Viviana De Luca, Claudiu T Supuran, Stefania De Luca, Clemente Capasso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valentina VerdolivaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Institute of Crystallography, National Research Council (CNR), Via Vivaldi, 43, 81100 Caserta, Italy.
Viviana De LucaDepartment of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Via P. Castellino, 111, 80131 Naples, Italy.ORCID 0000-0003-3406-833X
Claudiu T SupuranNeurofarba Department, Section of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0003-4262-0323
Stefania De LucaDepartment of Biomedical Sciences, Institute of Biostructures and Bioimaging, National Research Council (CNR), Via P. Castellino, 111, 80131 Naples, Italy.ORCID 0000-0002-7078-1696
Clemente CapassoDepartment of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Via P. Castellino, 111, 80131 Naples, Italy.ORCID 0000-0003-3314-2411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetazolamide (AZA) is a validated carbonic anhydrase inhibitor (CAI) that has the potential for use in various therapeutic applications. Herein, we report a novel AZA-loaded biodegradable nanodelivery system that was proven to enhance the antibacterial efficacy of the drug against Gram-negative bacteria, such as

Indexed as

AcetazolamideCarbonic Anhydrase InhibitorsCarbonic AnhydrasesEscherichia coliHyaluronic AcidNanoparticlesAnti-Bacterial AgentsDrug CarriersDrug Delivery SystemsDrug LiberationAcetazolamideAnti-Bacterial AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesDrug CarriersHyaluronic Acidacetazolamidebacterial metabolismbiomaterial-based drug carriercarbonic anhydrasehyaluronic acid

Identifiers

PMID40430049
PMCPMC12111950

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.