Evidence map›Paper›PMID 40430086›Full record

ArticleInternational journal of molecular sciences2025

A New Method of Canine CD4

Iwona Monika Szopa, Kinga Majchrzak-Kuligowska, Rafał Pingwara, Marek Kulka, Monika Taşdemir, Małgorzata Gajewska

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iwona Monika SzopaDepartment of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.ORCID 0000-0002-6831-9937
Kinga Majchrzak-KuligowskaDepartment of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.
Rafał PingwaraDepartment of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.ORCID 0000-0001-8650-1161
Marek KulkaDepartment of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.
Monika TaşdemirDepartment of Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0001-8782-7139
Małgorzata GajewskaDepartment of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.ORCID 0000-0001-7249-8627

Funding

Foundation for Polish Science POIR.04.04.00-00-3EE9/17-00National Science Center 2023/49/N/NZ5/03656Warsaw University of Life Sciences Science development fund
6 · The paper itself

Abstract

Th17 lymphocytes are a distinct subpopulation of T cells that are characterized by the production of interleukins IL-17, IL-21, IL-22, and IL-26, and high expression of RORγt. These cells play an important role in inflammation and autoimmune diseases. Recent studies using rodent and human models have also highlighted their promising properties as agents in cellular immunotherapy for cancer. However, much less is known about the properties of canine Th17 lymphocytes, despite the domestic dog being an important model used in comparative medicine. In this study, we developed methods of activation and differentiation of canine CD4

Indexed as

CD4-Positive T-LymphocytesCell DifferentiationMitochondriaTh17 CellsAnimalsCells, CulturedDogsInterleukin-17Lymphocyte ActivationPhenotypeWnt Signaling PathwayInterleukin-17domestic dog modelinterleukin-17magnetic EpoxyBeadsmemory phenotypeT cell activationT cell metabolismTh17 lymphocytesWnt/β-catenin signaling pathway

Identifiers

PMID40430086
PMCPMC12112516

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.