Evidence map›Paper›PMID 40430394›Full record

ArticleMolecules (Basel, Switzerland)2025

Exploring Multivalent Architectures for Binding and Stabilization of

Maria Giulia Davighi, Francesca Clemente, Giampiero D'Adamio, Macarena Martínez-Bailén, Alessio Morano, Andrea Goti, Amelia Morrone, Camilla Matassini, Francesca Cardona

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Recent advances in mucopolysaccharidosis IVA treatment.Orphanet journal of rare diseases · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria Giulia DavighiDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-1788-567X
Francesca ClementeDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-9899-0836
Giampiero D'AdamioDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-2054-1862
Macarena Martínez-BailénDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-6924-5151
Alessio MoranoDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0009-0002-1236-826X
Andrea GotiDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-1081-533X
Amelia MorroneLaboratory of Molecular Biology of Neurometabolic Diseases, Neuroscience Department, Meyer Children's Hospital IRCCS, Viale Pieraccini 24, 50139 Firenze, Italy.ORCID 0000-0003-2890-8179
Camilla MatassiniDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-8336-383X
Francesca CardonaDepartment of Chemistry "U. Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-6766-4624

Funding

A. Morrone also thanks PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE - Bando 2022 Award Number: Project code 20228S5LWYMUR Dipartimenti di Eccellenza 2023-2027 (DICUS 2.0)#NEXTGENERATIONEU (NGEU) funded by the Ministry of University and Research (MUR) Bando 2022, Award Number: Project code 2022N9E847Regione Toscana (Bando Salute 2018) Project Lysolate
6 · The paper itself

Abstract

Morquio A syndrome is a lysosomal disorder caused by the deficiency of the lysosomal enzyme

Indexed as

ChondroitinsulfatasesCycloaddition ReactionEnzyme StabilityHumansMucopolysaccharidosis IVProtein BindingRecombinant ProteinsChondroitinsulfatasesGALNS protein, humanRecombinant Proteinsdendrimersenzyme stabilizersiminosugarsMorquio Amultivalent glycomimeticsN-acetylgalactosamine 6-sulfatase

Identifiers

PMID40430394
PMCPMC12113998

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.