Evidence map›Paper›PMID 40430756›Full record

ArticlePathogens (Basel, Switzerland)2025

Hydrogen Sulfide (H

Kai Ma, Jingwen Huang, Jin Zhang, Yuan Tian, Jing Hu, Linhao Ma, Changnan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kai MaLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai 200444, China.ORCID 0009-0003-1014-8965
Jingwen HuangLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Jin ZhangGeneral Practice Department, Shanghai Pudong New District Kangqiao Community Health Service Center, Shanghai 201315, China.
Yuan TianLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Jing HuLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Linhao MaDepartment of Emergency Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200081, China.
Changnan WangLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai 200444, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is a life-threatening condition that is characterized by systemic inflammation and organ dysfunction, with adrenal dysfunction being a significant complication. This study aimed to investigate the role of necroptosis and hydrogen sulfide (H

methodsA cecal ligation and puncture (CLP)-induced sepsis mouse model was employed. Adrenocortical-specific mixed lineage kinase domain-like pseudokinase (MLKL) knockout (MLKL-KO) and cystathioneine β-synthase (CBS) knockout (CBS-KO) mice were generated using Cre-loxP technology and adrenocortical-specific Cre tool mice. In vitro experiments utilized TNFα-stimulated Y1 adrenocortical cells. The treatments included the H

resultsSepsis induced adrenal congestion, elevated TNFα levels, and activated necroptosis (increased p-MLKL/p-RIPK1) in wild-type mice. H

conclusionsH

Indexed as

Adrenal GlandsHydrogen SulfideNecroptosisSepsisTumor Necrosis Factor-alphaAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutProtein KinasesHydrogen SulfideMLKL protein, mouseProtein KinasesTumor Necrosis Factor-alphaadrenal dysfunctiongene knockout micehydrogen sulfidenecroptosissepsisTNFα

Identifiers

PMID40430756
PMCPMC12113818

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.