Evidence map›Paper›PMID 40431477›Full record

ArticleNutrients2025

The Protective Effects of Pectic Polysaccharides on Dextran Sulfate Sodium-Induced Colitis in

Zhenou Sun, Tianyu Qi, Boyu Cheng, Yingxiao Guo, Dima Atehli, Steve W Cui, Ji Kang, Qingbin Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Frontiers in pharmacology · 2026
    Article
  3. Structural characterization andFrontiers in nutrition · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenou SunState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.
Tianyu QiState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.
Boyu ChengState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.
Yingxiao GuoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.
Dima AtehliState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.
Steve W CuiGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
Ji KangState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.
Qingbin GuoState Key Laboratory of Food Nutrition and Safety, College of Food Science and Technology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.

Funding

the National Natural Science Foundation of China 32402076
6 · The paper itself

Abstract

backgroundPectic polysaccharides exhibit therapeutic potential against intestinal inflammation. However, the influence of structural variations on their efficacy remains largely unexplored.

methodsThis study investigated the structural and anti-inflammatory relationships of okra pectin (OP), citrus pectin (CP), apple pectin (AP), and hawthorn pectin (HP). Based on FT-IR spectra, CP was identified as a high-methoxyl pectin, with a degree of methyl esterification (DM) of 72.07 ± 3.86%. OP, AP, and HP were low-methoxyl pectins with the following DM values: 19.34 ± 3.04%, 32.11 ± 1.71%, and 38.67 ± 2.75%, respectively.

resultsMonosaccharide composition analysis revealed that OP exhibited the highest abundance of RG-I regions among all the samples. Homogalacturonan (HG) was the predominant structural region in AP and HP, while CP contained both of the aforementioned structural regions. Our findings demonstrated that OP and CP significantly ameliorated dextran sulfate sodium (DSS)-induced colitis in the wild-type

conclusionsThese findings first suggest that abundant RG-I structures and low molecular weight endowed pectins with significant anti-inflammatory activity.

Indexed as

Anti-Inflammatory AgentsColitisPectinsAnimalsDextran SulfateDisease Models, AnimalDrosophila melanogasterMalePolysaccharidesSignal TransductionStructure-Activity RelationshipAnti-Inflammatory AgentsDextran SulfatePectinsPolysaccharidesmolecular weightpectic polysaccharidestructure–activity relationshipulcerative colitis

Identifiers

PMID40431477
PMCPMC12113875

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.