Evidence map›Paper›PMID 40432062›Full record

ReviewVaccines2025

Maternal Immunization: Current Evidence, Progress, and Challenges.

Veronica Santilli, Mayla Sgrulletti, Giorgio Costagliola, Alessandra Beni, Maria Felicia Mastrototaro, Davide Montin, Caterina Rizzo, Baldassarre Martire, Michele Miraglia Del Giudice, Viviana Moschese and 1 more

Abstract readReview
In one paragraph

Review in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Missed opportunities for maternal immunisation against influenza and COVID-19, Norway, October 2023 to May 2024: a population-based registry study.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Veronica SantilliResearch Unit of Clinical Immunology and Vaccinology, Academic Department of Pediatrics (DPUO), IRCCS Bambino Gesù Children's Hospital, 00165 Rome, Italy.ORCID 0000-0003-1329-6827
Mayla SgrullettiPediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-7493-5226
Giorgio CostagliolaSection of Pediatric Hematologyand Oncology, Azienda Ospedaliero Universitaria Pisana, 56126 Pisa, Italy.ORCID 0000-0002-4160-3727
Alessandra BeniDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-6995-4791
Maria Felicia MastrototaroPediatrics and Neonatology Unit, Maternal-Infant Department, "Monsignor A.R. Dimiccoli" Hospital, 70051 Barletta, Italy.
Davide MontinDivision of Pediatric Immunology and Rheumatology, "Regina Margherita" Children Hospital, 10126 Turin, Italy.
Caterina RizzoDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Baldassarre MartirePediatrics and Neonatology Unit, Maternal-Infant Department, "Monsignor A.R. Dimiccoli" Hospital, 70051 Barletta, Italy.
Michele Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 81100 Naples, Italy.ORCID 0000-0002-8369-5957
Viviana MoschesePediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-7650-0632
Italian Society of Pediatric Allergy and Immunology (SIAIP) Vaccine Committee

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal immunization is a key strategy for protecting pregnant individuals and newborns from infectious diseases. This review examines the mechanisms and benefits of maternal immunization, with a focus on transplacental IgG transfer and immune system interactions. We provide an overview of current recommendations and the safety and efficacy profiles of maternal vaccines, including influenza, tetanus-diphtheria-acellular pertussis (Tdap), respiratory syncytial virus (RSV), COVID-19, and hepatitis B. Additionally, we analyze the barriers to maternal immunization, such as misinformation, vaccine hesitancy, and disparities in healthcare access, while exploring potential strategies to overcome these challenges through targeted educational initiatives, improved provider communication, and policy-driven interventions aimed at increasing vaccine confidence and accessibility. Finally, this review highlights recent innovations and future directions in maternal immunization, including emerging vaccines for Group B Streptococcus and cytomegalovirus. Expanding immunization programs and advancing research on maternal-fetal immunity are essential to optimizing vaccination strategies, improving public health outcomes, and reducing the global burden of infectious diseases.

Indexed as

COVID-19hepatitis Bimmunizationimmunologyinfluenzamaternalpertussispregnancy

Identifiers

PMID40432062
PMCPMC12115776

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.