ArticleJournal of biomedical research2025
Monocyte to HDL cholesterol ratio predicts obesity-associated cardiac dysfunction.
Article in Journal of biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Tracking Lipoprotein(a) Risk Through Inflammatory Biomarkers.Acta Cardiologica Sinica · 2026Article
- The association between the monocyte-to-HDL cholesterol ratio and coronary collateral circulation in patients with chronic total occlusion.BMC cardiovascular disorders · 2025Article
- Inflammatory Markers and Dyslipidemia in Patients with Oral Lichen Planus: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the prevalence of obesity increases dramatically, obesity-associated cardiac dysfunction constitutes a considerable challenge to human health. This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction. By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients, we found that both the plasma level of high-density lipoprotein cholesterol (HDL-C) and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction (LVEF). Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio (MHR) was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone. Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function. Collectively, our results demonstrate a superior role of MHR in predicting the risk of an obesity-associated decline in cardiac systolic function among routine metabolic/inflammatory markers.
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Registered trials
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