Evidence map›Paper›PMID 40432322›Full record

ArticleCancer biomarkers : section A of Disease markers2025

Internalization of extracellular double-stranded DNA as a potential marker of cancer stem cells in Epstein-Barr virus-induced B-cell lymphoma.

Evgeniya V Dolgova, Sofya G Oshikhmina, Yaroslav R Efremov, Vera S Ruzanova, Anastasia S Proskurina, Svetlana S Kirikovich, Evgeniy V Levites, Genrikh S Ritter, Oleg S Taranov, Olga Y Leplina and 5 more

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In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Evgeniya V DolgovaInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Sofya G OshikhminaInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Yaroslav R EfremovInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Vera S RuzanovaInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Anastasia S ProskurinaInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Svetlana S KirikovichInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Evgeniy V LevitesInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Genrikh S RitterInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Oleg S TaranovState Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia.ORCID 0000-0002-6746-8092
Olga Y LeplinaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Alexandr A OstaninResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.ORCID 0000-0001-6895-938X
Elena R ChernykhResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.ORCID 0000-0003-2346-6279
Dmitry N StrunkinSanitas Clinic, Novosibirsk, Russia.ORCID 0000-0003-4357-7443
Nikolay A KolchanovInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Sergey S BogachevInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.ORCID 0000-0002-2019-9382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundAt present, there are no universal markers of tumor stem cells known, including for B-lymphomas. Previously, we have shown that Epstein-Barr virus-induced B-cell lymphoma culture contains cells capable of internalizing TAMRA-labeled DNA. These cells form sphere-forming centers and are essential for the development of xenografts genetically identical to the initial culture.ObjectiveTo analyze the stem characteristics of cells that internalize DNA.MethodsSorting and RNA sequencing of two subpopulations (TAMRA + and TAMRA-) of Epstein-Barr virus-induced B-cell lymphoma culture and a series of quantitative real-time reverse transcription PCR were performed.ResultsTAMRA + cells were shown to have increased synthesis of mRNA of genes associated with the maintenance of a poorly differentiated state (

Indexed as

Biomarkers, TumorDNAEpstein-Barr Virus InfectionsHerpesvirus 4, HumanLymphoma, B-CellNeoplastic Stem CellsAnimalsCell Line, TumorHumansMiceBiomarkers, TumorDNAfluorescence-activated cell sortingRNAseqTAMRA-labelled double-stranded DNA probeWnt-signaling pathway

Identifiers

PMID40432322
PMCPMC12288411

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.