ArticleInnovation (Cambridge (Mass.))2025
Thalamic burst and tonic firing selectively indicate patients' consciousness level and recovery.
Article in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Advances in local field potential research in prolonged disorders of consciousness: a narrative review.Chinese neurosurgical journal · 2026Review
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- Adversarial AI reveals mechanisms and treatments for disorders of consciousness.Nature neuroscience · 2026Article
- Mapping the human thalamus: a historical review of thalamic atlases from histology to modern neuroanatomy.Frontiers in neuroanatomy · 2026Review
- Transcranial temporal interference stimulation of the thalamus in a patient with disorders of consciousness: a case report.Frontiers in human neuroscience · 2026Article
- A shared central thalamus mechanism underlying diverse recoveries in disorders of consciousness.Nature communications · 2025Article
- Neural mechanism of conscious perception for potential clinical applications.Clinical and translational medicine · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
Patients with disorders of consciousness suffer from severe impairments in arousal and awareness alongside anomalous brain connections and aberrant neuronal activities. The thalamus, a crucial hub in the brain connectome, has been empirically inferred to maintain consciousness and wakefulness. Here, we investigated thalamic spiking, brain connectivity, consciousness states, and recovery outcomes following deep brain stimulation in 29 patients. Our study reveals that thalamic neuronal activity serves as a marker of consciousness state. Patients diagnosed with vegetative state/unresponsive wakefulness syndrome exhibited less-active neurons, with longer and more variable burst discharges, than those in a minimally conscious state. Furthermore, neuronal profiles in the intralaminar thalamus, the direct stimulation site, predicted whether electrostimulation here improved recovery. Stronger tonic firing was correlated with enhanced thalamocortical connectivity and better recovery outcomes in patients. These findings suggest that thalamic spiking signatures, including single-neuron burst discharge and tonic firing, selectively indicate the representation and alteration of consciousness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.