ArticleFrontiers in pediatrics2025
Genetic polymorphisms of antioxidant enzymes (GSTP1/CAT/HMOX1/EPHX1) and childhood asthma risk in Fuzhou.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A Multilevel Redox-Based Prognostic Model for Asthma Severity: From Genotype to Serum Biomarkers.Biomedicines · 2026Review
- The Role of Oxidative Stress in the Pathogenesis of Childhood Asthma: A Comprehensive Review.Children (Basel, Switzerland) · 2025Review
- Decoding Asthma Therapy: The Role of VEGFA and HIF1A in Yanghe Pingchuan Granule's Mechanism.IET systems biologyArticle
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Discuss the correlation between single nucleotide polymorphisms (SNPs) of the Glutathione s-transferase Pi-1 (GSTP1), Catalase (CAT), Heme oxygenase-1 (HMOX1), and Homo sapiens epoxide hydrolase 1 (EPHX1) genes and the risk of childhood asthma in Fuzhou. Methods: Next generation sequencing ( Results: The rs1695 A>G variant increased the risk of asthma in the heterozygous, dominant, and allele models. The rs4891 T>C variant increased the risk of asthma in the heterozygous, dominant, and allele models. The rs7943316 A>T variant increased the risk of asthma in the homozygous, recessive, and allele models. The rs769217 C>T variant decreased the risk of asthma in the homozygous, recessive, and allele models. Strong linkage disequilibrium between the GSTP1 gene rs1695 and rs4891, and the CAT gene rs7943316, rs1049982, and rs769217. The GC haplotype composed of GSTP1 gene rs1695 and rs4891 may pose a risk for childhood asthma [ Conclusion: The genotype GC, composed of GSTP1 gene rs1695 and rs4891, may represent a risk genotype for childhood asthma, whereas genotype AT may represent a protective genotype for childhood asthma. The genotype ATT, composed of CAT gene rs7943316, rs1049982, and rs769217, may represent a protective genotype for childhood asthma. The combination of GSTP1 gene rs1695 and CAT gene rs7943316 constitutes the optimal model for predicting the risk of childhood asthma in the Fuzhou region.
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