ArticleFrontiers in neuroscience2025
Melatonin rhythm disorder is more pronounced in major depressive disorder with non-suicidal self-injury.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Alterations in serum melatonin, IL-6 and BDNF levels and their clinical correlations in first-episode major depressive disorder.Annals of general psychiatry · 2026Article
- Temporal dynamics of shame and guilt in adolescent NSSI: an ambulatory assessment study.Frontiers in psychiatry · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Introduction: Disruptions in melatonin (MT) rhythms have been linked to major depressive disorder (MDD) and may be further associated with non-suicidal self-injury (NSSI). This study investigates whether MDD patients with NSSI exhibit more pronounced MT rhythm disturbances and whether these disruptions correlate with NSSI-related thoughts and the motivation to cease self-injury. Methods: The study included 100 participants aged 14-24 years, including 30 healthy controls (HC) and 70 inpatients diagnosed with MDD. The MDD group was further divided into those with NSSI (NSSI group, Results: Melatonin levels were significantly lower across all six time points in the NSSI group compared to both the Non-NSSI and HC groups ( Conclusion: Lower MT levels and disrupted circadian rhythms are associated with NSSI in MDD patients, highlighting a potential link between circadian dysfunction and self-injurious behaviors. Further research is needed to clarify the underlying mechanisms of this association.
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