ReviewClinical ophthalmology (Auckland, N.Z.)2025
The Role of Scleral Changes in the Progression of Myopia: A Review and Future Directions.
Review in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological mechanisms of atropine in myopia control (Review).Molecular medicine reports · 2026Pooled it
- Review
- Network pharmacology and molecular dynamics simulations reveal shared mechanisms and myopia-specific targets of atropine in myopia and dry eye disease.Eye and vision (London, England) · 2026Article
- Interpretable machine learning model based on blood parameters for screening high myopia.Eye (London, England) · 2026Article
- Sustained activation of Wnt/β-catenin signaling in the retina of form-deprived myopic chicks.BMC genomics · 2026Article
- Myo-inflam: a mini review on inflammatory pathways driving scleral remodeling and axial elongation.Frontiers in immunology · 2026Review
- Defining the critical axial length threshold for transition from physiological growth to pathological fundus structural remodeling in adolescent myopia.Frontiers in cell and developmental biology · 2026Article
- Pyroptosis-associated inflammasome activation contributes to scleral remodeling in experimental myopia.International journal of ophthalmology · 2026Article
- Cellular Biological Basis and Novel Breakthroughs in the Pathogenesis of Myopia - A Narrative Review.International journal of general medicine · 2026Review
- Comprehensive analysis of the TGF-β signaling pathway: molecular mechanisms, disease drivers, and frontiers in clinical translation.Frontiers in immunology · 2026Review
- The "Three-Tier Regulatory Network" of Orthokeratology in Myopia Control: Evidence Weight of Underlying Mechanisms, Controversies, and New Perspectives for Clinical Translation--A Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Increased sensitivity to myopia and altered retinal ON/OFF balance in a mouse model lackingbioRxiv : the preprint server for biology · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- The role of inflammation in myopic retinopathy.Frontiers in ophthalmology · 2025Review
- Reticular fiber distribution in sclera: Key to understanding pathologic myopia and posterior staphylomas.Molecular vision · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review article comprehensively examines the alterations in scleral collagen fibers and the extracellular matrix (ECM) during myopia progression, with a particular focus on the scleral hypoxia theory and inflammatory mechanisms. It delves into key signaling pathways, including the matrix metalloproteinase - 2 (MMP-2) pathway, hypoxia - inducible factors (HIF-1α and HIF-2α) pathways, and the Wnt signaling pathway. By elucidating the intricate relationships between these signaling pathways, this article highlights the latest advancements in myopia prevention and control strategies that target the sclera. Moreover, it provides novel insights into the molecular mechanisms underlying scleral remodeling and explores their potential therapeutic applications for effectively managing myopia progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.