Evidence map›Paper›PMID 40433553›Full record

ArticleHemaSphere2025

Characterization of cancer-associated fibroblasts and their spatial architecture reveals heterogeneity and survival associations in classic Hodgkin lymphoma.

Suvi-Katri Leivonen, Kristiina Karihtala, Teijo Pellinen, Marja-Liisa Karjalainen-Lindsberg, Tomohiro Aoki, Christian Steidl, Sirpa Leppä

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suvi-Katri LeivonenResearch Programs Unit, Applied Tumor Genomics, Faculty of Medicine University of Helsinki Helsinki Finland.ORCID 0000-0003-3224-0757
Kristiina KarihtalaResearch Programs Unit, Applied Tumor Genomics, Faculty of Medicine University of Helsinki Helsinki Finland.ORCID https://orcid.org/0000-0002-8807-8624
Teijo PellinenInstitute for Molecular Medicine Finland (FIMM) Helsinki Finland.ORCID https://orcid.org/0000-0001-9652-7373
Marja-Liisa Karjalainen-LindsbergDepartment of Pathology Helsinki University Hospital Helsinki Finland.ORCID https://orcid.org/0000-0001-6728-2266
Tomohiro AokiCentre for Lymphoid Cancer, BC Cancer Vancouver British Columbia Canada.ORCID https://orcid.org/0000-0001-6782-8361
Christian SteidlCentre for Lymphoid Cancer, BC Cancer Vancouver British Columbia Canada.ORCID https://orcid.org/0000-0001-9842-9750
Sirpa LeppäResearch Programs Unit, Applied Tumor Genomics, Faculty of Medicine University of Helsinki Helsinki Finland.ORCID 0000-0002-8265-511X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) are a heterogeneous population of stromal cells, which modulate the immune system and can have both pro- and anti-tumorigenic effects. In classic Hodgkin lymphoma (cHL), the role of CAFs has remained largely undefined. We applied multiplexed immunofluorescence imaging and spatial analysis on tumor samples from two independent cHL patient cohorts (

Identifiers

PMID40433553
PMCPMC12107116

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.