SynthesisFrontiers in cellular and infection microbiology2025
Association between oral dysbiosis and Parkinson's disease: a systematic review.
Synthesis in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral dysbiosis in children with renal failure: a systematic review.Frontiers in dental medicine · 2026Pooled it
- Periodontal health in a longitudinal French cohort of people with Parkinson's disease.Scientific reports · 2026Observational
- The Oral Microbiome and Systemic Health: Current Insights into the Mouth-Body Connection.Life (Basel, Switzerland) · 2026Review
- Integrative meta-analysis of the OSCC microbiome: from niche-specific heterogeneity to universal network and functional signatures.Journal of oral microbiology · 2026Article
- Comparative Study of Patients with Periodontal and Parkinson's Disease: Clinical and Salivary Aspects.Biomedicines · 2025Article
- Gut Microbiome as a Source of Probiotic Drugs for Parkinson's Disease.International journal of molecular sciences · 2025Review
- Sex-dependent alterations of salivary microbiome in Parkinson's disease: associations with motor and non-motor clinical phenotypes.Frontiers in molecular biosciences · 2025Article
- Leveraging microbiome-based interventions to improve the management of neurodegenerative diseases: evidence for effects along the microbiota-gut-brain axis.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral cavity serves as the gateway to the human organism, hosting a diverse community of microorganisms that coexist in a state of symbiosis. Disruption of this balance leads to oral dysbiosis, a condition associated with infections and oral pathologies, which may contribute to the etiopathogenesis of systemic disorders such as Parkinson's disease, a neurodegenerative movement disorder characterized by resting tremor, rigidity, and bradykinesia. While oral dysbiosis is recognized as a risk factor and an aggravating element for Parkinson's disease, it is not regarded as a direct cause. This systematic review aims to synthesize existing research exploring the potential relationship between oral dysbiosis and the development of Parkinson's disease. Following a comprehensive analysis, 12 studies were selected, comprising 11 case-control studies and one observational analytical study. These studies investigated the composition of oral microbiota in different sample groups, revealing a higher abundance of pathogenic oral bacteria in individuals diagnosed with Parkinson's disease. The findings suggest that oral dysbiosis may influence both the onset of Parkinson's disease and the progression of symptoms such as cognitive decline. These results pave the way for future research, particularly regarding alterations in oral microbiota as potential biomarkers for early diagnosis and disease monitoring. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024540056.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.