Evidence map›Paper›PMID 40433895›Full record

Trial reportAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Nucleotides as an Anti-Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study).

Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05243108 (A Randomized Controlled Trial Study to Evaluated the Effect of Exogenous Nucleotides As an Anti-ageing Supplement in Older Adults), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05243108 nacompletednot on this map

A Randomized Controlled Trial Study to Evaluated the Effect of Exogenous Nucleotides As an Anti-ageing Supplement in Older Adults (60-70 Years)

TypeinterventionalSponsorPeking UniversityRan2022 to 2023Enrolled122ConditionsAgingArmsdietary nucleotides, placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuyue WangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Lixia SongDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Rui FanDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Qianqian ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Ruisheng FuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Mei YouDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Yuxiao WuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Meng CaiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Yong LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.
Meihong XuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, China.ORCID https://orcid.org/0000-0001-7201-6982

Funding

Zhen-ao Group Co., Ltd. (Dalian, China)
6 · The paper itself

Abstract

Aging impairs nutrient metabolism and accelerates biological aging, negatively affecting health and longevity. The Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs) trial (ClinicalTrials.gov: NCT05243108) aimed to explore whether nucleotides (NTs) supplementation can delay biological aging and improve health outcomes in the elderly. The trial is a 19-week, double-blind, randomized, placebo-controlled study in Chengdu, China, with 121 participants (60-70 years). Participants are randomly assigned to either NTs (1.2 g day

Indexed as

AgingDietary SupplementsNucleotidesAgedChinaDNA MethylationDouble-Blind MethodFemaleHumansMaleMiddle AgedNucleotidesanti‐aging interventionbody compositionDNA methylation ageinsulin sensitivitynucleotides supplementation

Identifiers

PMID40433895
PMCPMC12412603

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.