ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Post-Translational Modifications in Cilia and Ciliopathies.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neddylation relieves cytoskeletal tension to permit primary cilia formation during mouse decidualization.Cell communication and signaling : CCS · 2026Article
- Post-Translational Modifications in Cilia and Ciliopathies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cilia are microtubule-based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis. Mutations in ciliary proteins are associated with a wide range of human diseases, collectively referred to as ciliopathies. The past decades have witnessed significant advances in the identification of post-translational modifications (PTMs) in ciliary proteins, as well as the enzymes responsible for the PTMs. For example, acetylation of α-tubulin at lysine 40 is essential for ciliary assembly and maintenance, while ubiquitination of centrosomal proteins, such as pericentriolar material 1, regulates ciliary disassembly. In addition, accumulating evidence has shown that PTMs are essential for modulating ciliary structure and function, and that dysregulation of these modifications leads to the development of ciliopathies. In this review, current knowledge of PTMs in ciliary proteins is summarized, and their roles in regulating ciliary formation, homeostasis, and signaling are highlighted. The contribution of aberrant ciliary PTMs to ciliopathies is also discussed, along with the potential of targeting PTMs for ciliopathy treatment, including pharmacological modulation of PTM-related enzymes or substrates, which may provide new avenues for therapeutic intervention in ciliopathies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.