Evidence map›Paper›PMID 40434284›Full record

ArticleClinical and translational science2025

GLP-1 Agonists for Pediatric Psychopharmacology: Opportunities and Cautions.

Michael Bartkoski, Ethan A Poweleit, Stephani L Stancil

Abstract read
In one paragraph

Article in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael BartkoskiDivision of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.ORCID 0000-0001-8203-4121
Ethan A PoweleitDivision of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.ORCID 0000-0001-6805-2243
Stephani L StancilDivision of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.ORCID 0000-0001-7308-3132

Funding

Childrens Mercy Hospital Fellowship Program in Pediatric PharmacologyT32HD069038 · NICHD · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Laura B Ramsey, Jonathan Wagner · 2011 to 2026
$3.1M
Development of a Pharmacodynamic Biomarker of Opioid Antagonism in Adolescents with Eating DisordersK23MH130728 · NIMH · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Stephani L Stancil · 2023 to 2026
$740k
NICHD NIH HHS T32 HD069038NIMH NIH HHS K23 MH130728
6 · The paper itself

Abstract

Glucagon-like peptide-1 agonists (GLP-1A) are increasingly prescribed to treat obesity and type 2 diabetes mellitus in children and adolescents. Emerging evidence suggesting neuropsychiatric effects presents an opportunity for pediatric psychopharmacology but requires careful consideration of potential adverse effects and risk of misuse. This perspective examines potential applications and cautions surrounding GLP-1As for pediatric mental health, particularly substance use, depression, and eating disorders, and advocates for research and clinical monitoring to ensure their safety and efficacy.

Indexed as

Glucagon-Like Peptide 1AdolescentChildDiabetes Mellitus, Type 2Feeding and Eating DisordersGlucagon-Like Peptide-1 Receptor AgonistsHumansPediatric ObesityPsychopharmacologySubstance-Related DisordersGlucagon-Like Peptide 1Glucagon-Like Peptide-1 Receptor Agonists

Identifiers

PMID40434284
PMCPMC12117883

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.