Evidence map›Paper›PMID 40434389›Full record

ArticleJournal of primary care & community health

Predicting Long-Term Health-Related Quality of Life in Individuals With Prior SARS-CoV-2 Infection: A 12-Month Prospective Study.

Ali A Weinstein, Leyla de Avila, Maria Stepanova, Jillian K Price, Carey Escheik, Lynn H Gerber, Zobair M Younossi

Abstract read
In one paragraph

Article in Journal of primary care & community health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Health-related quality of life changes in patients with Q-fever fatigue syndrome: a four-year follow-up study, 10 years post-infection.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ali A WeinsteinInova Fairfax Medical Campus, Falls Church, VA, USA.ORCID 0000-0002-3371-6086
Leyla de AvilaInova Fairfax Medical Campus, Falls Church, VA, USA.
Maria StepanovaInova Fairfax Medical Campus, Falls Church, VA, USA.
Jillian K PriceInova Fairfax Medical Campus, Falls Church, VA, USA.ORCID 0000-0003-4150-2835
Carey EscheikInova Fairfax Medical Campus, Falls Church, VA, USA.
Lynn H GerberInova Fairfax Medical Campus, Falls Church, VA, USA.
Zobair M YounossiInova Fairfax Medical Campus, Falls Church, VA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify predictors of clinically meaningful declines in health-related quality of life (HRQoL) among COVID-19 patients over a 12-month period in a prospective, natural history investigation.

methodsWe conducted a longitudinal study involving individuals who had tested positive for SARS-CoV-2, assessing various factors and their impact on HRQoL after 12 months. Key potential predictors examined included demographic information, medical history, and symptom reporting. HRQoL was measured using the validated EuroQoL Dimension 5 level scale at baseline and at the 12-month follow-up.

resultsThe analysis revealed that shortness of breath, a diagnosis of COPD, lower BMI, and a history of anxiety at the initial visit were all significantly associated with clinically meaningful worsening of HRQoL at 12 months. Specifically, individuals with these factors experienced more pronounced declines in HRQoL compared to those without. Notably, the small number of COPD cases within our sample (4 total) limited the reliability of this predictor.

conclusionsShortness of breath, lower BMI, and a history of anxiety are important predictors of deteriorated HRQoL in COVID-19 patients over the long term. Although the association with COPD is less reliable due to sample size limitations, these findings highlight the need for targeted interventions and continued support for patients exhibiting these risk factors to improve long-term HRQoL outcomes. Future research with larger samples is needed to confirm these results and further investigate the role of these factors in post-COVID HRQoL declines.

Indexed as

COVID-19Quality of LifeAdultAgedAnxietyBody Mass IndexDyspneaFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesPulmonary Disease, Chronic ObstructiveSARS-CoV-2anxietybody-mass indexCOPDfunctionSARS-CoV-2shortness of breath

Identifiers

PMID40434389
PMCPMC12120274

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.