Evidence map›Paper›PMID 40434644›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut.

Biao He, Meilin Li, Shuai Guo, Feng Zhu, Zhiwei Jiao, Jianyong Li, Nie Tan, Shiming Jiao, Taiping Liu, Jian Zhang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Host complement C3 promotes malaria transmission by killing symbiotic bacteria in the mosquito midgut.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Biao HeDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Meilin LiDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Shuai GuoDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.ORCID 0009-0008-0957-4189
Feng ZhuDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Zhiwei JiaoState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Jianyong LiDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Nie TanDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Shiming JiaoDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Taiping LiuDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Jian ZhangDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Yongling FanDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Yuanli GaoDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Taoli ZhouDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.
Jian LiState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.ORCID 0000-0002-6397-2785
Wei HuangKey Laboratory of Molecular Virology and Immunology, Shanghai institute of immunity and infection, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200030, China.
Lubin JiangKey Laboratory of Molecular Virology and Immunology, Shanghai institute of immunity and infection, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200030, China.ORCID 0000-0001-6307-470X
Zurui LinDvision of Malaria Control, Yunnan Institute of Parasitic Diseases, Pu'er, Yunnan 655000, China.
Sibao WangNew Cornerstone Science Laboratory, Chinese Academy of Sciences Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200030, China.ORCID 0000-0002-5880-0815
Wenyue XuDepartment of Pathogenic Biology, Army Medical University, Chongqing 400038, China.ORCID 0000-0003-3681-5052

Funding

MOST | National Natural Science Foundation of China (NSFC) 82302570MOST | National Natural Science Foundation of China (NSFC) 82372287the State Key Program of The National Natural Science Foundation of China 81830067
6 · The paper itself

Abstract

Host-derived factors ingested during mosquito blood feeding are poorly understood modulators of malaria transmission. Here, we demonstrated that host complement C3, acquired by mosquitoes during

Indexed as

AnophelesComplement C3MalariaMalaria, FalciparumMosquito VectorsAnimalsFemaleHost-Parasite InteractionsHumansMicePlasmodium falciparumSymbiosisComplement C3complement C3malaria parasitemicrobiotamosquitoestransmission

Identifiers

PMID40434644
PMCPMC12146734

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.