ArticleScience advances2025
Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges.Apoptosis : an international journal on programmed cell death · 2026Review
- Kv2-VAP interactions enhance presynaptic ER and mitochondrial calcium influx and the mobilization of vesicles from the reserve pool.bioRxiv : the preprint server for biology · 2026Article
- Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells.The Journal of physiology · 2025Article
- Robust inhibitory glycinergic transmission and the effect of bafilomycin, folimycin and EIPA: lessons from the auditory brainstem.Frontiers in cellular neuroscience · 2025Article
- Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells.bioRxiv : the preprint server for biology · 2024Article
- Vesicle and reaction-diffusion hybrid modeling with STEPS.Communications biology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic transmission is driven by a complex cycle of vesicle docking, release, and recycling, maintained by distinct vesicle pools. However, the partitioning of vesicle pools and reserve pool recruitment remain poorly understood. We use a novel vesicle modeling technology to model the synaptic vesicle cycle in unprecedented molecular and spatial detail at a hippocampal synapse. Our model demonstrates robust recycling of synaptic vesicles that maintains consistent synaptic release, even during sustained high-frequency firing. We also show how the cytosolic proteins synapsin-1 and tomosyn-1 cooperate to regulate recruitment of reserve pool vesicles during sustained firing to maintain transmission, as well as the potential of selective vesicle active zone tethering to ensure rapid vesicle replenishment while minimizing reserve pool recruitment. We also monitored vesicle usage in isolated hippocampal neurons using pH-sensitive pHluorin, demonstrating that reserve vesicle recruitment depends on firing frequency, even at nonphysiologically high firing frequencies, as predicted by the model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.