Evidence map›Paper›PMID 40435500›Full record

ArticleJMIR aging2025

Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study.

Victoria Grace Gabb, Jonathan Blackman, Hamish Morrison, Haoxuan Li, Adrian Kendrick, Nicholas Turner, Rosemary Greenwood, Bijetri Biswas, Amanda Heslegrave, Elizabeth Coulthard

Abstract read
In one paragraph

Article in JMIR aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Comparison of Sleep Architecture in Individuals Aged 65 to 80 Years With and Without Mild Cognitive Impairment Using Multi-Channel Sleep Monitoring.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Adoption of Telemedicine for Dementia Care in Nigeria: Scoping Review.Interactive journal of medical research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria Grace GabbBristol Medical School, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-7688-766X
Jonathan BlackmanBristol Medical School, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-9579-9860
Hamish MorrisonBristol Medical School, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-9358-7936
Haoxuan LiBristol Medical School, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0009-0008-7120-8657
Adrian KendrickUniversity of the West of England, Bristol, United Kingdom.ORCID https://orcid.org/0009-0001-2291-8272
Nicholas TurnerBristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0003-1591-6997
Rosemary GreenwoodResearch & Innovation, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-6637-5225
Bijetri BiswasSchool of Electrical, Electronic and Mechanical Engineering, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0003-3995-2693
Amanda HeslegraveInstitute of Neurology, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-7290-6405
Elizabeth CoulthardBristol Medical School, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-0017-9595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleep holds promise as a modifiable risk factor for neurodegenerative diseases and dementia. Clinical trials to modify sleep in people at risk of or in the early stages of dementia are needed. Monitoring natural sleep from home could support pragmatic and decentralized large-scale clinical trials. However, whether longitudinal sleep research can be successfully delivered remotely in this population has not been established yet.

objectiveWe investigated the feasibility of remote longitudinal research using wearable devices, web-based cognitive tasks, and a smartphone app to record sleep and cognition in older adults with mild cognitive impairment (MCI) or dementia.

methodsOlder adults with MCI or dementia due to Alzheimer disease or Lewy body disease and cognitively healthy participants completed at-home sleep and circadian monitoring (digital sleep diaries, actigraphy, wearable sleep electroencephalography, and saliva samples) and digital cognitive assessments for 8 weeks. Feasibility outcomes included recruitment, retention, and data completeness.

resultsIn total, 41 participants consented (n=10, 24% participants with Alzheimer disease; n=11, 27% participants with Lewy body disease; and n=20, 49% controls). There were predominantly male and White British participants, with a mean age of 70.9 (SD 5.9) years. Retention was very high, with 40 (98%) participants completing 8 weeks of remote monitoring. Data completeness for sleep electroencephalography was 91% and ranged from 79% to 97% for all remote tasks and was overall high across all participant subgroups. In total, 30% (12/40) of participants reported receiving external support with completing study tasks.

conclusionsHigh rates of retention, data completeness, and data quality suggested that longitudinal multimodal sleep and cognitive profiling using novel and remote monitoring technology is feasible in older adults with MCI and dementia and healthy older adults, even without study partner support. Remote monitoring should be considered for mechanistic and interventional trials. Careful consideration should be given to how to ensure remote monitoring technologies reduce burden and enhance inclusivity, particularly in communities traditionally underserved by research and those with lower digital literacy. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/52652.

Indexed as

CognitionCognitive DysfunctionDementiaSleepActigraphyAgedAged, 80 and overAlzheimer DiseaseFeasibility StudiesFemaleHumansLongitudinal StudiesMaleProspective Studiesactigraphydementiadigital biomarkerselectroencephalographyfeasibilitymild cognitive impairmentremote study designsalivasleep

Identifiers

PMID40435500
PMCPMC12159556

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.