Evidence map›Paper›PMID 40436017›Full record

ArticleCell2025

Cross-organ metabolite production and consumption in healthy and atherogenic conditions.

Hosung Bae, Sunhee Jung, Johnny Le, Ian Tamburini, Joohwan Kim, Eric Wang, Won-Suk Song, Wonsuk Choi, Ki-Hong Jang, Taekyung Kang and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Hosung BaeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Sunhee JungDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Johnny LeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Ian TamburiniDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Joohwan KimDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Eric WangDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Won-Suk SongDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Wonsuk ChoiDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Ki-Hong JangDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Taekyung KangDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Miranda L LopezDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Cuauhtemoc RamirezDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Miranda E KellyDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Jessie KimDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Raymond KimDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Sang Hee ParkDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Jongwon BaekDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Bryan MendezDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Paul PetrusDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden.
Thomas Q de Aguiar VallimDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Dequina A NicholasDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA.
Quinton SmithDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA; Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA.
Gina LeeDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.
Marcus SeldinDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA. Electronic address: mseldin@uci.edu.
Cholsoon JangDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA. Electronic address: choljang@uci.edu.

Funding

CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Sex Differences in lipid antigen presentation, impact of lipid antigen presentation on peripheral lipid metabolismDP2AI171121 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Dequina Angelina Nicholas · 2022 to 2026
$2.8M
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
Physicochemical control of multilineage emergenceR35GM151099 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Quinton Smith · 2023 to 2026
$1.5M
Elucidating the regulation of RNA methylation by mTOR signaling in cancerK22CA234399 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, GINA · 2022 to 2023
$440k
Elucidating alcohol-induced metabolic remodeling of critical organsR21AA030358 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON, SELDIN, MARCUS MICHAEL · 2023 to 2023
$412k
Elucidating the role of nonessential amino acid metabolism in diabetic skin woundsF31DK134173 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI Johnny Le · 2023 to 2026
$197k
NCI NIH HHS K22 CA234399NCI NIH HHS T32 CA009054NIAAA NIH HHS R01 AA029124NIAAA NIH HHS R21 AA030358NIAID NIH HHS DP2 AI171121NIDDK NIH HHS F31 DK134173NIGMS NIH HHS R35 GM151099NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

Mammalian organs continuously produce and consume circulating metabolites for organismal health and survival. However, the landscape of this fundamental process and its perturbation by diet and disease is unknown. Using arteriovenous metabolomics, tissue transcriptomics, and hormone arrays in multiple pathophysiological conditions in pigs, we generated an atlas of 10 cross-organ metabolite production and consumption during fasting/feeding, Western diet, and cardiovascular disease progression induced by low-density lipoprotein receptor (LDLR) deficiency. We discovered numerous instances of feeding-dependent and -independent metabolite production and consumption by organs and proposed mechanisms by which these are disrupted by Western diet via altered metabolite concentration gradients and hormones. Both Western diet and LDLR deficiency trigger the release of bile acids (BAs) by extra-hepatic organs, likely contributing to abnormally elevated circulating BA levels and consequent vascular inflammation and atherosclerosis development. These resources reveal intricate inter-organ metabolic crosstalk across pathophysiological conditions, offering biochemical insights into diet effects and cardiometabolic diseases.

Indexed as

AtherosclerosisAnimalsBile Acids and SaltsDiet, WesternFastingFemaleHumansLiverMaleMetabolomeMetabolomicsReceptors, LDLSwineBile Acids and SaltsReceptors, LDLarteriovenous metabolomicsbile acid metabolismcardiovascular diseasecirculating metabolitefluxinter-organ exchangeisotope tracinglow-density lipoprotein receptormetabolomicswestern diet

Identifiers

PMID40436017
PMCPMC12335369

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.