Evidence map›Paper›PMID 40436522›Full record

ArticleJACC. Basic to translational science2025

β-Hydroxybutyrate Facilitates Homeostasis of Hypoxic Endothelial Cells After Myocardial Infarction via Histone Lysine β-Hydroxybutyrylation of CPT1A.

Zhaoyue Li, Yutong Guo, Jie Xiong, Liyan Bai, Hao Tang, Bo Wang, Bingchen Guo, Yi Qiu, Guanghui Li, Manyu Gong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
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  4. Article
  5. Review
  6. From Fuel to Code: How Ketones Drive Coronary Revascularization.JACC. Basic to translational science · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhaoyue LiHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Department of Cardiology, Affiliated Hospital of Yangzhou University, Institute of Cardiovascular Disease, Yangzhou Key Lab of Innovation Frontiers in CVD, Yangzhou, China.
Yutong GuoHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jie XiongHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Liyan BaiHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hao TangHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bo WangHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bingchen GuoHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yi QiuHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Guanghui LiHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Manyu GongHarbin Medical University, Harbin, China; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Lin LvHarbin Medical University, Harbin, China; Experimental Animal Center, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zengxiang DongHarbin Medical University, Harbin, China; Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital of Harbin Medical University, Harbin, China; NHC Key Laboratory of Cell Transplantation, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: dongzx@hrbmu.edu.cn.
Yingfeng TuHarbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: tyfdoctor@hrbmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) initiates a robust angiogenic response crucial for tissue repair. β-hydroxybutyrate (BHB) is an essential circulating metabolite, and its role in angiogenesis under pathological conditions remains unclear. We evaluated the coronary collateral circulation in 114 patients with MI and investigated its correlation with serum BHB levels. High BHB levels were found to correlate with better collateral circulation. Moreover, BHB promotes angiogenesis post-MI in vivo and in vitro. Mechanistically, BHB modulates the epigenetic landscape in hypoxic endothelial cells by increasing H3K9bhb levels associated with the transcriptional activation of angiogenesis-related genes and enhancing chromatin accessibility at loci associated with these genes. The integrated analysis of RNA sequencing, cleavage under targets and tagmentation, and assay for transposase-accessible chromatin with sequencing identified carnitine palmitoyltransferase 1a as a key proangiogenic target. Thus, BHB nutritional supplementation may represent a promising therapeutic strategy for ischemic heart disease, with high potential for clinical translation.

Indexed as

angiogenesisCPT1Amultiomicsmyocardial infarctionβ-hydroxybutyrateβ-hydroxybutyrylation

Identifiers

PMID40436522
PMCPMC12235315

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.