ArticleNature communications2025
Bioadhesive hydrogel-coupled and miniaturized ultrasound transducer system for long-term, wearable neuromodulation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07190287 (Evaluation of a Wearable EEG-tFUS System for REM Sleep Modulation in Healthy Adults and Individuals With Subclinical Sleep Disturbances), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Wearable EEG-tFUS System for REM Sleep Modulation in Healthy Adults and Individuals With Subclinical Sleep Disturbances
Who cites it
20 citing papers in PubMed.
- Skin-attached bioadhesive patch enabling ultrasound deep brain stimulation and real-time electrophysiological monitoring for REM sleep enhancement.Nature communications · 2026Trial
- Tailored construction and functional applications of conductive hydrogels for bioelectronic interfaces.Discover nano · 2026Review
- Materials-Structure-Hardware-Algorithm Co-Driven Hierarchical Optimization for Flexible Sensors.Nano-micro letters · 2026Review
- Solid Hydrogel Couplants for Skin Superficial Blood Flow Imaging With Super-Resolution Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Neural dynamics of temporal interference stimulation monitoring by soft liquid metal interfaces across neural systems.Nature communications · 2026Article
- Focused ultrasound neuromodulation for psychiatric disorders: a scoping review of clinical applications and current progress.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Wearable ultrasound: a review of core technologies and clinical applications in cardiovascular monitoring.Microsystems & nanoengineering · 2026Review
- Hydrogel-integrated multimodal physiological and modulation systems.Materials horizons · 2026Review
- Multi-Functional Adaptive Interfaces for Next-Generation Wearable and Implantable Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Organoid Brain-Machine-Interface Devices for Central Nervous System Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Conductive Hydrogel-Enabled Electrode for Scalp Electroencephalography Monitoring.Small methods · 2026Review
- Advances and Prospects of Wearable Ultrasound Devices.Micromachines · 2026Article
- Sonogenetics for precision medicine: from molecular toolkit to clinical translation.Theranostics · 2026Review
- A Wearable Ultrasound Sensing System for Soft Tissue Stiffness Detection: A Feasibility Study.Biosensors · 2025Article
- Mimicking focused ultrasound with a loop coil in acoustic radiation force imaging.Magnetic resonance in medicine · 2025Article
- Multifunctional hydrogel sensors with dynamic covalent networks for machine learning-assisted Parkinson's disease diagnosis and encrypted human-computer interaction.Materials today. Bio · 2025Article
- Acoustic Coupling for Double-Blind Human Low-Intensity Focused Ultrasound Neuromodulation.bioRxiv : the preprint server for biology · 2025Article
- Wearable devices in neurological disorders: a narrative review of status quo and perspectives.Annals of translational medicine · 2025Review
- A Wearable EMG-Driven Closed-Loop TENS Platform for Real-Time, Personalized Pain Modulation.Sensors (Basel, Switzerland) · 2025Article
- Hydrogels in wearable neural interfaces.Med-X · 2024Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Transcranial focused ultrasound is a promising non-invasive method for neuromodulation, particularly for neurodegenerative and psychiatric conditions. However, its use in wearable systems has been limited due to bulky devices and reliance on ultrasound gel, which dehydrates and lacks stable adhesion for long-term use. Here, we present a miniaturized wearable ultrasound device, comparable in size to standard electrophysiological electrodes, integrated with a bioadhesive hydrogel for stable, long-term somatosensory cortical stimulation. Our air-cavity Fresnel lens based self-focusing acoustic transducer was fabricated via a lithography-free microfabrication process, achieving 30.7 W/cm² (1.92 MPa) acoustic intensity and 10 mm focal depth. The hydrogel couplant exhibited less than 13% acoustic attenuation and maintained a stable adhesion force of 0.961 N/cm for 35 days. Using this system, we successfully suppressed somatosensory evoked potentials elicited by functional electrical stimulation over 28 days, demonstrating the device's potential for long-term, wearable neuromodulation applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.