ArticleScientific reports2025
Causal relationship between glycemic traits and inflammatory eye diseases and their complications, and myopia: a Mendelian randomization analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Unraveling causal pathways in retinal vein occlusion: a systematic review of Mendelian randomization studies.International journal of retina and vitreous · 2025Review
- Mendelian Randomization Studies of Myopia: Choosing the Right Summary Statistics.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Current evidence on glycemic traits' causal links to inflammatory eye diseases, complications, and myopia remains limited and inconsistent, particularly regarding glucose regulation. This study evaluates specific indicators to address these knowledge gaps. A two-sample Mendelian randomization framework from a genome-wide association study was used. Causal estimates were obtained using inverse variance weighting (IVW), MR-Egger, weighted median, simple model and weighted model methods. Cochran Q test, MR-Egger regression, MR-PRESSO and leave-one-out analysis were used to assess heterogeneity and pleiotropy. Higher proinsulin levels correlated with glaucoma and POAG risks (OR = 1.263, 95%CI = 1.020-1.563, P = 0.032; OR = 1.409, 95%CI = 1.075-1.846, P = 0.01). Higher BMI and fasting insulin were cataract risk factors (OR = 1.261, 95%CI = 1.135-1.401, P < 0.001; OR = 1.645, 95%CI = 1.100-2.460, P = 0.015); BMI is a risk factor for keratitis (OR = 1.463, 95%CI = 1.071-1.997, P = 0.017). Adiponectin protected against chronic conjunctivitis (OR = 0.464, 95%CI = 0.265-0.811, P = 0.007), HbA1c against retinal vein occlusion (OR = 0.266, 95%CI = 0.105-0.675, P = 0.005). High adiponectin reduced myopia (OR = 0.99, 95% CI = 0.984-0.997, P = 0.003), while high HbA1c increased it (OR = 1.018, 95% CI = 1.008-1.027, P < 0.001). Glycemic profiles increase the risk for inflammatory eye diseases and complications including keratitis, glaucoma, and cataracts but protect against chronic conjunctivitis and retinal vein occlusion. Low adiponectin and high HbA1c raise myopia risk. Targeting modifiable factors (physical activity/sugar intake) suggests novel myopia prevention strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.