Evidence map›Paper›PMID 40437141›Full record

ArticleMedical oncology (Northwood, London, England)2025

Cx43 mediates cross-talk of tumor cells and macrophage via cGAS-STING signaling.

Yu Gao, Yusheng Liang, Weize Yu, Xiaoming Tan, Gaojian Zhuang, Bing Li, Jiayi Huang, Jinghao Zheng, Xuanqi Yang, Leyun Wen and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu Gao *Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital. No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Yusheng Liang *Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital. No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Weize Yu *College of Pharmacy, Dali University, No. 22, Wanhua Road, Xiaguan Town, Dali Yunnan, 671000, China.
Xiaoming Tan *Qingyuan Maternal and Child Healthcare Hospital, No. 22, Shuguang 2nd Road, Qingcheng District, Qingyuan, 511500, Guangdong, China.
Gaojian ZhuangAffiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital. No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Bing LiAffiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital. No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Jiayi HuangAffiliated Qingyuan Hospital, The Sixth Clinical Medical School, Qingyuan People's Hospital, Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Jinghao ZhengAffiliated Qingyuan Hospital, The Sixth Clinical Medical School, Qingyuan People's Hospital, Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Xuanqi YangAffiliated Qingyuan Hospital, The Sixth Clinical Medical School, Qingyuan People's Hospital, Guangzhou Medical University, No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Leyun WenAffiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital. No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China.
Lingling SunDepartment of Pharmacy, and Engineering Research Center of Tropical Medicine Innovation and Transformation, The First Clinical College, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Yuan ZhangAffiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital. No. 35, Yinquan North Road, Qingcheng District, Qingyuan, 511518, Guangdong, China. zhangyuanlazy@gzhmu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province No. 2024A1515220102National Natural Science Foundation of China No. 82304532
6 · The paper itself

Abstract

Tumor microenvironment (TME) plays a pivotal role in immunotherapy, especially in immune checkpoint inhibitors (ICIs) therapy, but how tumor cells and immune cells cross-talk with each other remains elusive. Thus, exploring the mechanisms is of urgent needs. Connexin 43 (Cx43) is a key gap junction (GJ) protein, which allows tumor cells and immune cells to interact. In this study, we systematically investigated the function of Cx43 in response to ICIs and observed that Cx43 promoted the activation of CD8

Indexed as

Connexin 43MacrophagesMembrane ProteinsNeoplasmsNucleotidyltransferasesAnimalsCD8-Positive T-LymphocytesCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansImmune Checkpoint InhibitorsMiceMice, Inbred C57BLSignal TransductionSTING ProteinTumor MicroenvironmentcGAS protein, humanConnexin 43Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGJA1 protein, humanImmune Checkpoint InhibitorsMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteincGAMPcGAS-STING signaling pathwayConnexin 43Macrophage

Identifiers

PMID40437141

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.